Efficacy Trials of Sorghum based Composite Flour Mix on the Blood Glucose Levels of Experimental Induced Hyperglycemic Rats

Jump To References Section

Authors

  • Manisha Sharma
     Department of Food Science and Nutrition, Assam Agricultural University, Jorhat, Assam-785 013 ,IN
  • Mamoni Das
     Department of Food Science and Nutrition, Assam Agricultural University, Jorhat, Assam-785 013 ,IN
  • Jadav Sarma
     Department of Pharmacology and Toxicology, Assam Agricultural University, Jorhat, Assam-785 013 ,IN
  • Alam S.
     Department of Horticulture, Assam Agricultural University, Jorhat, Assam-785 013 ,IN

DOI:

https://doi.org/10.21048/IJND.2021.58.2.26727

Keywords:

Non- Communicable Diseases, Blood Glucose Level, Dietary Fibre, Phytonutrients, Obesity, Diabetes

Abstract

Diabetes is global health disorder affecting millions of people worldwide with the largest number of diabetic adults in India ranging around 61.3 million people. Use of indigenous foods has been advocated to reduce the incidence of chronic, diet related non-communicable diseases such as diabetes, obesity and CVD. In the present study an approach was made to develop and assess the functional efficacy of sorghum based composite flour mix for a period of 15 days on blood glucose level of alloxan induced diabetes rats. Out of all the seven groups, Group A showed no significant improvement in the blood sugar level at the end of the supplementation period, Group B showed significant increase in the blood glucose level while Group C showed significant decrease in the blood glucose level along with Groups D, E, F and G fed with sorghum based composite flour mix showed significant decrease in the blood sugar level. Thus it can be concluded that the blood glucose lowering effect of sorghum based composite flour may be due to the in situ composition of the composite flour mix which are potential sources of dietary fibres like cellulose, lignin, phytonutrients including tannins, phenolic acids, anthocyanins, phytosterols, polyphenols, and policosanols. 

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2021-05-18

How to Cite

Sharma, M., Das, M., Sarma, J., & S., A. (2021). Efficacy Trials of Sorghum based Composite Flour Mix on the Blood Glucose Levels of Experimental Induced Hyperglycemic Rats. The Indian Journal of Nutrition and Dietetics, 58(2), 244–256. https://doi.org/10.21048/IJND.2021.58.2.26727

Issue

Volume 58, Issue 2, April-June 2021

Section

Original Articles

License

All the articles published in IJND are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

Please contact us at editor@informaticsglobal.com for permissions related to commercial use of the article(s).

Crossref
Scopus
Google Scholar
Europe PMC
Received 2021-01-05
Accepted 2021-04-12
Published 2021-05-18

 

References

Grewal, A. and Jood, S. Effect of processing treatments on nutritional and anti-nutritional contents of green gram. J. Fd. Biochem., 2006, 30, 535-546. DOI: https://doi.org/10.1111/j.1745-4514.2006.00080.x

Katoch, R. Nutritional potential of rice bean (Vigna umbellata): An underutilized legume. J. Fd. Sci., 2015,

Uadia, R. Effect of aqueous extract of Canavalia ensiformis seeds on hyperlipidaemia and hyperketonaemia in alloxan-induced diabetic rats. Biochem., 2003, 15, 7-15.

Bansal, V., Kapur, G.S., Sarpal, A.S., Kagdiyal, V., Jain, S.K., Srivastava, S.P. and Bhatnagar, A.K. Estimation of total aromatics and their distribution as mono and global di-plus aromatics in diesel-range products by NMR spectroscopy. Energy fuels, 2012, 12, 1223-1227. DOI: https://doi.org/10.1021/ef980052y

Szkudlarz, S. and Bajerska, J. Phytochemicals as functional bread compounds: Physiological effects. Bread and its Fortification, CRC Press, Boca Raton, 2016, 79-101.

Oliveira Otto, M.C., Otite, F.O., Abioye, A.I. and Mozaffarian, D. Effects of saturated fat, polyunsaturated fat, monounsaturated fat and carbohydrate on glucose-insulin homeostasis: A systematic review and meta-analysis of randomised controlled feeding trials. F.Chem., 2014, 132, 186-193.

Gerstein, H.C., Miller, M.E., Genuth, S., Ismail-Beigi, F., Buse, J.B., Goff, J.D. and Grimm, J.R. Long-term effects of intensive glucose lowering on cardiovascular outcomes. The New Eng. J. Med., 2011, 364, 818-828. DOI: https://doi.org/10.1056/NEJMoa1006524

Sharma, M., Das, M. and Alam, S. Development of functional flour using malted cereals and legumes. 2018.

Florián, J., Bardales-Valdivia, J., Caruajulca-Guevara, L. and Cueva-Llanos, D. Anti-diabetic effect of Coffea arabica, in alloxan-induced diabetic rats. Emirates J. Fd. Agricul., 2013, 65, 772-777. DOI: https://doi.org/10.9755/ejfa.v25i10.16409

Lenzen, S. and Panten, U. Alloxan: history and mechanism of action. Diabetologia, 1988, 31, 337-342. DOI: https://doi.org/10.1007/BF02341500

Johnston, K.L., Clifford, M.N. and Morgan, L.M. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. The Am. J. Clin. Nutr., 2003, 78, 728-733. DOI: https://doi.org/10.1093/ajcn/78.4.728

Shobana, S., Sreerama, Y. N. and Malleshi, N. G. Composition and enzyme inhibitory properties of finger millet (Eleusine coracana L.) seed coat phenolics: Mode of inhibition of α-glucosidase and pancreatic amylase. Fd. Chem., 2009, 115, 1268-1273. DOI: https://doi.org/10.1016/j.foodchem.2009.01.042

Taylor, J. R. and Emmambux, M. N. Developments in our understanding of sorghum polysaccharides and their health benefits. Cereal Chem., 2010, 87, 263-271. DOI: https://doi.org/10.1094/CCHEM-87-4-0263

Kim, S.H., Jo, S.H., Kwon, Y.I. and Hwang, J.K. Effects of onion (Allium cepa L.) extract administration on intestinal α-glucosidases activities and spikes in postprandial blood glucose levels in SD rats model. Int. J. Molec. Sci., 2011, 12, 3757-3769. DOI: https://doi.org/10.3390/ijms12063757

Hooda, S. and Jood, S. Effect of soaking and germination on nutrient and anti-nutrient contents of fenugreek (Trigonella foenum graecum L.). J. Fd. Biochem., 2012, 27, 165-176. DOI: https://doi.org/10.1111/j.1745-4514.2003.tb00274.x

Khan, M.I., Anjum, F.M., Sohaib, M. and Sameen, A. Tackling metabolic syndrome by functional foods. 2013, 14, 287-297 DOI: https://doi.org/10.1007/s11154-013-9270-8

Singh, J. and Kakkar, P. Anti-hyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J. Ethnopharmacol., 2009, 123, 22-26. DOI: https://doi.org/10.1016/j.jep.2009.02.038

Butler, J., Rodondi, N., Zhu, Y., Figaro, K., Fazio, S., Vaughan, D.E. and Holvoet, P. Metabolic syndrome and the risk of cardiovascular disease in older adults. Journal of the Am. Coll. Cardiol., 2006, 47, 1595-1602. DOI: https://doi.org/10.1016/j.jacc.2005.12.046

Guimaraes, H. P. Effect of low glycemic index food on blood glucose control versus conventional control in patients with type 2 diabetes mellitus: A systematic review with meta"analysis of randomized controlled trials. Cardiovas. Therap., 2001, 31, 147-160. DOI: https://doi.org/10.1111/j.1755-5922.2011.00308.x

Shepherd, J., Barter, P., Carmena, R., Deedwania, P., Fruchart, J. C., Haffner, S. and Waters, D. Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: The Treating to New Targets (TNT) study. Diabet. Care, 2006, 29, 1220-1226. DOI: https://doi.org/10.2337/dc05-2465

Hardy, K. Dental calculus reveals potential respiratory irritants and ingestion of essential plantbased nutrients at lower Palaeolithic Qesem Cave Israel. Quaternary Int., 2009, 398, 129-135. DOI: https://doi.org/10.1016/j.quaint.2015.04.033

Mohanraj, R., Sivasankar, S., Kumar, M., Madhusudhan, B. and Ravishankar, G. Sweet Potato (Ipomoea batatas [L.] Lam) - A valuable medicinal food: A review. J. Med. Fd., 2014, 17, 733-741. DOI: https://doi.org/10.1089/jmf.2013.2818

Ray, K.K., Seshasai, S.R.K., Wijesuriya, S., Sivakumaran, R., Nethercott, S., Preiss, D. and Sattar, N. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: A meta-analysis of randomised controlled trials. The Lancet, 2009, 373, 1765-1772. DOI: https://doi.org/10.1016/S0140-6736(09)60697-8

Morris, J.K. and Wald, N.J. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. 2009.

Vaisey-Genser, M. and Morris, D. H. Introduction: History of the cultivation and uses of flaxseed, 2003, 45, 13-33. DOI: https://doi.org/10.1201/9780203437506-5

Mani, U. and Iyer, U. Role of Spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. J. Med. Fd., 2001, 4, 193-199. DOI: https://doi.org/10.1089/10966200152744463

Kelly, T.N., Bazzano, L.A., Fonseca, V.A., Thethi, T.K., Reynolds, K. and He, J. Systematic review: Glucose control and cardiovascular disease in type 2 diabetes. Ann. Int. Med., 2009, 151, 394-403. DOI: https://doi.org/10.7326/0003-4819-151-6-200909150-00137

Heidemann, C., Schulze, M.B., Franco, O.H., van Dam, R.M., Mantzoros, C.S. and Hu, F.B. Dietary patterns and risk of mortality from cardiovascular disease, cancer and all-causes in a prospective cohort of women: Heidemann-dietary patterns and mortality. Circula., 2008, 118, 230 DOI: https://doi.org/10.1161/CIRCULATIONAHA.108.771881

Lee, M.K., Park, Y.B., Kang, M.A. and Choi, M.S. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. The Int. J. Biochem. cell Boil., 2006, 38, 1134-1145. DOI: https://doi.org/10.1016/j.biocel.2005.12.002

Müeller, G., Tschank, G., Seipke, G., Habermann, P., Kurrle, R. and Tennagels, N. In vitro metabolic and mitogenic signaling of insulin glargine and its metabolites. 2010, 5, 9540. DOI: https://doi.org/10.1371/journal.pone.0009540