Molecular Docking and Therapeutic Targets of Flavanol Compounds from Camellia sinensis on Alzheimer’s Disease

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Authors

  • Nandhini Baskaran
     Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu ,IN
  • Anitha Subash
     Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu ,IN

DOI:

https://doi.org/10.21048/IJND.2022.59.2.29907

Keywords:

Alzheimer’s disease, acetylcholinesterase, catechin, epicatechin-3-gallate, docking, Camellia sinensis

Abstract

Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding

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Published

2022-05-11

How to Cite

Baskaran, N., & Subash, A. (2022). Molecular Docking and Therapeutic Targets of Flavanol Compounds from <i>Camellia sinensis</i> on Alzheimer’s Disease. The Indian Journal of Nutrition and Dietetics, 59(2), 152–158. https://doi.org/10.21048/IJND.2022.59.2.29907

Issue

Volume 59, Issue 2, April-June 2022

Section

Original Articles

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Received 2022-04-01
Accepted 2022-04-04
Published 2022-05-11

 

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