In Vitro Amelioration by Curcumin on Genotoxicity in Workers with Elevated Blood Cadmium Level

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Authors

  • Ambar Pathan
     Cell biology Lab., Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380 009, India. ,IN
  • Ankit Nariya
     Cell biology Lab., Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380 009, India. ,IN
  • Naumita Shah
     Cell biology Lab., Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380 009, India. ,IN
  • Idrish Shaikh
     National Institute of Occupational Health (Indian Council of Medical Research), Meghani Nagar, Ahmedabad 380016, India ,IN
  • Jayesh Vyas
     National Institute of Occupational Health (Indian Council of Medical Research), Meghani Nagar, Ahmedabad 380016, India ,IN
  • Devendrasinh Jhala
     Cell biology Lab., Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380 009, India. ,IN

DOI:

https://doi.org/10.18311/jnr/2017/15752

Keywords:

Cadmium, Curcumin, Free Radical Toxicity, Genotoxicity, PBLC
Biological ScienceS

Abstract

Curcumin is a dietary element, easily available and also well-known herb, for its therapeutic uses. On the other hand, cadmium is considered as an omnipresent, hazardous, heavy metal as well as known carcinogen, clastogen and mutagen. It is known to produce severe toxic effects during occupational exposure in industries related to nickel-cadmium batteries, pigments, chemical stabilizers, metal coatings and alloys in humans. So, the objective of this study was to evaluate the ameliorative effects of curcumin as an antioxidant agent against cadmium induced genotoxicity in Peripheral Blood Lymphocyte Cultures (PBLC) of occupationally cadmium exposed individuals. The blood cadmium level was determined and it was significantly higher in exposed individuals as compared to controls. Blood samples from 40 workers exposed to cadmium, and 40 unexposed controls were used to analyse biochemical parameters like Total protein, GSH, GPx, GR, GST, LPO, CAT and SOD along with genotoxic parameters like SCEs, CCPI, AGT and PDT. The study revealed cadmium induced the free radicals formation which caused alteration in antioxidant defense system and may lead to genotoxicity. While curcumin ameliorates this toxicity by balancing the antioxidant defense system, decrease the lipid peroxidation and ultimately protect cells against cadmium genotoxicity. Hence, it can be concluded that curcumin which is herbal antidote can be helpful to protect cadmium toxicity in occupationally exposed workers.

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Published

2017-08-07

How to Cite

Pathan, A., Nariya, A., Shah, N., Shaikh, I., Vyas, J., & Jhala, D. (2017). In Vitro Amelioration by Curcumin on Genotoxicity in Workers with Elevated Blood Cadmium Level. Journal of Natural Remedies, 17(1), 20–27. https://doi.org/10.18311/jnr/2017/15752

Issue

Volume 17, Issue 1, January 2017

Section

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