Preliminary Evaluation of Hepatoprotective Activity of <I>Trianthema portulacastrum</I> Linn

R. S. Mehta; M. B. Shankar; M. Geetha; A. K. Saluja

doi:10.18311/jnr/2003/160

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Authors

R. S. Mehta
,IN
M. B. Shankar
,IN
M. Geetha
,IN
A. K. Saluja
,IN

DOI:

https://doi.org/10.18311/jnr/2003/160

Keywords:

Trianthema portulacastrum, Hepatoprotective Activity, Paracetamol, Rifampicin, Silymarin.

Therapeutic Drug Monitoring

Abstract

Objective: To study hepatoprotective effect of aerial parts of Trianthema portulacastrum. Materials and methods: Hepatoprotective activity of T. portulacastrum was evaluated using paracetamol and rifampicin as liver toxicants in rats. The potency of alcoholic and aqueous extracts of aerial parts was compared with that of silymarin at a dose of 100 mg/kg, P.O. The SGOT, SGPT and bilirubin levels of blood were measured spectrophotometrically. Results: Alcoholic extract of aerial parts caused significant fall in the enzyme levels in serum in rats. Conclusion: T. portulacastrum has shown significant activity in rats toxicated with paracetamol and rifampicin and can be recommended for further studies.