Anti-Nociceptive Activity of Mundulea sericea Leaves

Abstract

Objective: To study the analgesic activity of leaves of Mundulea sericea. Methods: Methanolic extract (30 mg/kg and 70 mg/kg) of Mundulea sericea (Leguminosae, subfamily Papilionaceae) was investigated for analgesic activity using acetic acid-induced writhing and tail immersion method. The extract was studied for its effect on pentobarbitone-induced sleep and on gross behavior. Results: Methanolic extract (30 mg/kg and 70 mg/kg) significantly increased latency to flick tail in tail immersion test and reduced the number of writhings induced by acetic acid. The extract increased the duration of pentobarbitone-induced sleep. No adverse effects were observed upto a dose of 200 mg/kg of the extract. Conclusion: Leaves of Mundulea sericea possess central as well as peripheral analgesic activity.