Evaluation of Aqueous Extract of Pulp and Seeds of Moringa oleifera for Wound Healing in Albino Rats

Abstract

Objective: To study the effect of aqueous extract of the dried pulp and seeds of Moringa oleifera on wound healing in albino rats. Materials and methods: The aqueous extract was studied at dose level of 300 mg/kg body weight using resutured incision; excision and dead space wound models in rats. Results: Significant increase in wound closure rate, skin-breaking strength, granuloma breaking strength, hydroxyproline content, granuloma dry weight and decrease in scar area was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results obtained, it may be concluded that the aqueous extract of Moringa oleifera has significant wound healing property. Also it can be concluded that these prohealing effects may be due to their high content of crude proteins, zinc and some anti-microbial component.