Phytochemical Characterization, In-Vitro Cytotoxic and Antibacterial Activity of Cotula cinerea (Delile) Vis Essential Oil

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Authors

  • Ben Amor M. Larbi
     University of Hamma Lakhdar El-Oued, B.P.789, 39000 ,DZ
  • Benchikha Naima
     University of Hamma Lakhdar El-Oued, B.P.789, 39000 ,DZ
  • Eman R. Elsharkawy
     Department of Ecophysiology, Desert Research Center, Mathaf El-Mataria, 15753 ,EG
  • N. Salah Neghmouche
     University of Hamma Lakhdar El-Oued, B.P.789, 39000 ,DZ

DOI:

https://doi.org/10.18311/jnr/2018/22380

Keywords:

Essential Oil Composition, GC/MS, HCT116, HePG2.
Natural product, Eniviroment

Abstract

Cotula cinerea is a traditional Algerian medicinal plant that has many biological properties, such as analgesic, antiseptic and antibacterial activities. Essential oil of Cotula cinerea was subjected to chromatographical and spectroscopical studies to determine the chemical composition. The analysis highlighted that the oil contains trans thujone (51.86%), santalina triéne (10.6%), α-pinéne (2.02%), sabinene (6.17%), cineole <1.8> (5.34%), δ-terpinene (1.57%), camphor (2.63%), β-terpineol (1.39 %) and terpin-4-ol (1.73%) as the major constituents. The essential oil was tested for antibacterial activity. The oil exhibited substantial antibacterial activity against both the tested Gram negative and Gram positive bacteria. In search of better anticancer agent the essential oil of Cotula cinerea was also subjected for in-vitro cytotoxic activity on two cancerous human cell lines; colon (HCT116) and hepatic (HePG2) cancer cell lines. The results indicates that the essential oil of Cotula cinerea has a significant cytotoxic activity on the tested colon cancer cell lines with a 66.9% inhibition and a minimal inhibition (33.9%) on liver cancer cell line.

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Published

2018-12-21

How to Cite

Larbi, B. A. M., Naima, B., Elsharkawy, E. R., & Salah Neghmouche, N. (2018). Phytochemical Characterization, <I>In-Vitro</I> Cytotoxic and Antibacterial Activity of <I>Cotula cinerea</I> (Delile) Vis Essential Oil. Journal of Natural Remedies, 18(3), 107–112. https://doi.org/10.18311/jnr/2018/22380

Issue

Volume 18, Issue 3, July 2018

Section

Articles
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Europe PMC

 

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