Evaluation of Effectiveness of Anti Hangover Oral Film in the Management of Alcohol Induced Hangover Symptoms

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Authors

  • J. C. Shobha
     Department of Clinical Pharmacology and Therapeutics, Hetero Healthcare Ltd., Hyderabad – 500081, Telangana ,IN
  • Tabitha Ohol
     Department of Clinical Pharmacology and Therapeutics, Hetero Healthcare Ltd., Hyderabad – 500081, Telangana ,IN

DOI:

https://doi.org/10.18311/jnr/2021/24664

Keywords:

Alcohol, Curcumin, Film, Hang Over

Abstract

Alcohol induced hangover symptoms are experienced the day after alcohol consumption. Curcumin is polyphenolic compound available in turmeric with strong antioxidant and anti-inflammatory properties. Curcumin is tested as one of the best, in alleviating the hangover symptoms. The anti-hangover properties of curcumin were evaluated in the present study. 42 subjects received the active anti-hangover oral film and 16 subjects received placebo. Subjects who received the active anti-hangover oral film showed complete absence of symptoms like dizziness, stomach ache and palpitation as compared to placebo. 2–5% of the subjects in the active group experienced headache, loss of appetite and nausea as compared to 56% to 87% in the placebo group. There was no problem with concentration at work in 71% of the subjects in the active group as compared to 38% in the placebo group. Relief from hangover symptoms was good to excellent in the active group as compared to no relief in the placebo group. The anti-hangover oral film containing curcumin was safe and effective in minimizing or completely eliminating the hangover symptoms.

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Published

2021-02-26

How to Cite

Shobha, J. C., & Ohol, T. (2021). Evaluation of Effectiveness of Anti Hangover Oral Film in the Management of Alcohol Induced Hangover Symptoms. Journal of Natural Remedies, 21(1), 71–76. https://doi.org/10.18311/jnr/2021/24664

Issue

Volume 21, Issue 1, January 2021

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2019-12-24
Accepted 2020-11-20
Published 2021-02-26

 

References

Lantman MS, Mackus M, Loo AJ, Verster JC. The impact of alcohol hangover symptoms on cognitive and physical functioning, and mood. Hum Psycho pharmacol Clin Exp. 2017; 32(5). https://doi.org/10 .1002/hup.2623. PMid:28750479 PMCid:PMC5638093

Verster JC, Herwijnen JV, Olivier B, Kahler CW. Validation of the Dutch version of the brief young adult alcohol consequences questionnaire (B-YAACQ). Addict Behav. 2009; 34(5):411–414. https://doi.org/10. 1016/j.addbeh.2007.09.013. PMid:17942242

Howland J, Rohsenow DJ, Edwards EM. Are some drinkers resistant to hangover? A literature review. Curr Drug Abuse Rev. 2008; 1(1):42-6. https://doi.org /10.2174/1874473710801010042. PMid:19630704

Srinivasan S, Dubey KK, Singhal RS. Influence of food commodities on hangover based on alcohol dehy drogenase and aldehyde dehydrogenase activities. Curr Res Nutr Food Sci. 2019; 1:8–16. https://doi.org/10 .1016/j.crfs.2019.09.001. PMid:32914100 PMCid:PM C7473379

Ambade A, Mandrekar P. Oxidative stress and inflammation: Essential partners in alcoholic liver disease. Int J Hepatol. 2012. https://doi.org/10.1155/ 2012/853175. PMid:22500241 PMCid:PMC3303590

Prat G, Adan A, Turet MS. Alcohol hangover: A critical review of explanatory factors. Hum Psychopharmacol Clin Exp. 2009; 24:259–67. https://doi.org/10.1002/ hup.1023. PMid:19347842

Lantman MS, Loo AJ, Mackus M, Verster JC. Development of a definition for the alcohol hangover: Consumer descriptions and expert consensus. Curr Drug Abuse Rev. 2016; 9:148–54. https://doi.org/10.2 174/1874473710666170216125822. PMid:28215179

Pabst AE, Devenney LE, Verster JC. Sex differences in the presence and severity of alcohol hangover symp toms. J Clin Med. 2019; 8:867. https://doi.org/10.3390/ jcm8060867. PMid:31213020 PMCid:PMC6617014

Swift R, Davidson D. Alcohol hangover: Mechanisms and mediators. Alcohol Health Res World. 1998; 22(1):54–60.

Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hshimoto T, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011; 34(5):660–5. https://doi. org/10.1248/bpb.34.660. PMid:21532153

Gopi S, Georgea R, Thankachen RU, Sriraam VT, Abirami S. Studies on the effectiveness, safety and tolerability of two doses of anti hangover drink in reducing alcohol induced hangover symptoms in adult male social drinkers. Int J Curr Res Aca. Rev. 2014; 2(8):125–31.

Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, et al. Drinkable preparation of theracurmin exhibits high absorption efficiency-a single-dose, double-blind, 4-way crossover study. Biol Pharm Bull. 2013; 36(11):1708–14. https://doi.org/ 10.1248/bpb.b13-00150. PMid:24189415