Grape Seed and Physalis Extracts as Anti- Inflammatory Agents in Cetuximab Induced Tongue Mucositis in Rats

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Authors

  • Heba A. Saleh
     Master degree in Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University ,EG
  • Manar A. Abdul Aziz
     Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University ,EG
  • Mona E. Wali
     Head of Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University ,EG

DOI:

https://doi.org/10.18311/jnr/2020/25070

Keywords:

Anti-inflammatory Effect, Cetuximab, Mucositis, Physalis peruviana
nutraceuticals / drug toxicity/ oral mucositis

Abstract

Background: Oral mucositis induced by cancer therapy alters cancer patient's life. Nutraceuticals these days is for their various activities which could neutralize the toxicity induced by cancer treatment. Purpose: Comparision between the effect of grape seed and fruits of Physalis peruviana methanol extract in reduction of mucositis induced by Cetuximab drug. Study Design: Animal study. Methods: 60 male rats divided into 6 groups as 10 in each group. Control group of rats with no intervention given. The other 5 groups were given Cetuximab drug alone or with grape seed extract (simultaneously or 1 week before Cetuximab drug) or Physalis extract (simultanously or 1 week before Cetuximab drug). After sacrifice, tongue was dissected and tissue preparation was done for all samples. Digital counting was done by image analyzer computer system for (a) filliform papillae in H&E stained sections, (b) mast cells in mast cell tryptase stained sections to assess inflammation. The area percent for bax immune-expression in other immune stained sections were also measured done to assess apoptosis. Results: The difference between the groups was assessed for statistical significance (P<0.0001) by ANOVA test. The greatest mean number of filiform papillae was recorded in control group I. Greatest mean number of mast cells and the greatest mean area percent of bax immune expression were recorded in group II. Conclusion: Grape seed extract and Physalis extract could neutralize the harmful effect of cancer therapy. Physalis extract had more potent effect in reducing the inflammation induced by Cetuximab drug.

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Published

2020-10-01

How to Cite

Saleh, H. A., Abdul Aziz, M. A., & Wali, M. E. (2020). Grape Seed and <i>Physalis</i> Extracts as Anti- Inflammatory Agents in Cetuximab Induced Tongue Mucositis in Rats. Journal of Natural Remedies, 20(3), 173–184. https://doi.org/10.18311/jnr/2020/25070

Issue

Volume 20, Issue 3, July 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-03-22
Accepted 2020-07-09
Published 2020-10-01

 

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