Analgesic and Anti-Inflammatory Activity of Methanolic Extract of Leaves of Quisqualis indica

Abstract

The present study was designed to evaluate the analgesic and anti-inflammatory activity of methanolic extract of Quisqualis indica (MEQI) leaves in rodents. The peripheral analgesic activity of methanolic extract of Quisqualis indica leaves (MEQI; 200 and 400 mg/kg) was studied using acetic acid-induced writhing test and central analgesic activity of MEQI was studied using hot-plate method in mice. Anti-Inflammatory activity of MEQI (200 and 400 mg/kg) was studied in carragenin induced paw edema in rats. MEQI significantly decreased the writhing movements in acetic acid-induced writhing test and increased the reaction time in hot-plate test in mice. MEQI also showed significant anti-inflammatory activity in carragenin induced paw edema by reducing paw volume in rats. From our study, we concluded that MEQI has potential analgesic and anti-inflammatory activities.