Effect of Ethanolic Extract of Leaves of Cocculus hirsutus (L.) Diels on Experimentally Induced Urothiliasis in Rats

Abstract

In the present study, we report anti-urolithiasis effect of ethanolic extract of leaves of Cocculus hirsutus (L.) Diels (CH-eth) on the biochemical and histopathological parameters against sodium oxalate (NaOx) induced urolithiasis model in rat. The increased severity of microscopic calcium oxalate (CaOx) crystal deposition along with increased CaOx concentration in kidney was seen after seven days of NaOx (70 mg/kg, i.p) pretreatment. CH-eth (100 and 200 mg/kg, p.o.) and standard marketed formulation, Cystone^® (500 mg/kg, p.o.) caused significant reversal of NaOx induced changes in ion excretion and urinary CaOx concentration in seven day treatement (prophylactic and therapeutic schedule). In conclusion, CH-eth showed beneficial effect against urolithiasis by decreasing CaOx excretion and preventing crystal deposition in kidney tubules.