A Pre-clinical Study of Jeerakadi Lepa against Indian Red Scorpion Venom Poisoning

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Authors

  • Pallavi Satyajit Kulkarni
     Manjushree Research Institute in Ayurvedic Science, Gujarat Ayurved University, Piplaj, Jamnagar, Gandhinagar - 382610, Gujarat. ,IN ORCID logo https://orcid.org/0000-0003-3528-9302
  • Narayan Gajanan Gramopaghye
     Dr. J. J. Magdum Ayurvedic Medical College, Maharashtra University of Health Sciences, Jaysingpur – Shirol Rd., Nashik, Jaysingpur - 416101. ,IN ORCID logo https://orcid.org/0000-0002-2746-3043
  • Satyajit Pandurang Kulkarni
     Manjushree Research Institute in Ayurvedic Science, Gujarat Ayurved University, Piplaj, Jamnagar, Gandhinagar - 382610, Gujarat. ,IN ORCID logo https://orcid.org/0000-0001-8154-9967

DOI:

https://doi.org/10.18311/jnr/2023/29361

Keywords:

Cumin Seeds, Indian Red Scorpion Poisoning, Jeerakadi Lepa, Mesobuthus tumulus, Preclinical Study, Vrischikdansha

Abstract

Scorpion stings are very common in India, especially in the Konkan region of Maharashtra state. Scorpion stings show various signs and symptoms. A preclinical study to validate the efficacy of an Ayurvedic preparation called Jeerakadi Lepa was done in Swiss albino mice. A total of 18 Swiss albino mice (n = 18) were divided into 3 groups: the control group (n = 6), the standard group (n = 6) and the experimental group (n = 6). Only Indian red scorpion venom was administered by the SC route in the control group. In contrast, the venom was administered by SC in the standard group, followed by an oral tablet. Prazosin, and in the experimental group, the venom was administered by SC route, followed by local Jeerakadi Lepa. Kruskal-Wallis’s test was applied at a 95% confidence interval to assess various toxicity parameters like lacrimation, salivation, etc. The P-value was 0.04433 in toxicity symptoms (P < 0.05), but it was 0.3366 (P > 0.05) in the number of deaths of Swiss albino mice in the above groups. It was concluded that Jeerakadi Lepa effectively eliminated all the signs and symptoms of toxicity due to scorpion venom in Swiss albino mice. Still, it should not be used independently among humans.

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Published

2023-03-23

How to Cite

Kulkarni, P. S., Gramopaghye, N. G., & Kulkarni, S. P. (2023). A Pre-clinical Study of Jeerakadi Lepa against Indian Red Scorpion Venom Poisoning. Journal of Natural Remedies, 23(1), 73–78. https://doi.org/10.18311/jnr/2023/29361

Issue

Volume 23, Issue 1, January 2023

Section

Research Articles

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Copyright (c) 2023 Pallavi Satyajit Kulkarni, Narayan Gajanan Gramopaghye, Satyajit Pandurang Kulkarni

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2022-01-20
Accepted 2022-12-01
Published 2023-03-23

 

References

Agrawal A, Kumar A, Consul S, Yadav A. Scorpion bite, a sting to the heart! Available from: www.ijccm.org

Sagarad SV, Singh Thakur B, Reddy, Balasubramanya SS, Joshi M, Kerure SB. NT-proBNP in Myocarditis after a Scorpion Sting Envenomation. J Clin Diagnostic Res. (Available from: www.jcdr.net) 2013; 7(1):118– 21. https://doi.org/10.7860/JCDR/2012/4858.2684 DOI: https://doi.org/10.7860/JCDR/2012/4858.2684

Binorkar SV, Parlikar GR. Epidemiology, presentation and integrated management of scorpion sting envenomation. Int J Pharmacol Toxicol. 2016; 4(1):33. https://doi.org/10.14419/ijpt.v4i1.5952 DOI: https://doi.org/10.14419/ijpt.v4i1.5952

Scorpion Sting: Clinical Manifestations, Management, and Literature - HS Bawaskar - Google Books [Internet]. [cited 2022 Jan 19]. Available from: https://books.google.co.in/books?hl=en&lr =&id=nr8kLWdK9jUC&oi=fnd&pg=PA1&dq=Ba waskar+HS,+scorpion+sting+clinical+manifestat ions,+management,+and+literature,+1998,+first+ edition,+popular+publication+Pvt.+Ltd.+Mumbai, +&ots=X-3-8-aH1d&sig=jflEMbX-UpHHJ0_BOX_ h9noPdeQ&redir_esc=y#v=onepage&q&f=false

Chippaux JP. Emerging options for the management of scorpion stings. Drug Des Devel Ther. [Internet Available from: /pmc/articles/PMC3401053/]. 2012; 6:165. https://doi.org/10.2147/DDDT.S24754 DOI: https://doi.org/10.2147/DDDT.S24754

Kale AA. A Crusade Against Scorpion Sting: Life and Works of Dr. Himmatrao Bawaskar. J Fam Med Prim Care. [Internet Available from: /pmc/ articles/PMC3893953/]. 2012; 1(1):52. https://doi. org/10.4103/2249-4863.94453 DOI: https://doi.org/10.4103/2249-4863.94453

Bawaskar HS, Bawaskar PH. Prazosin in management of cardiovascular manifestations of scorpion sting. Lancet (London, England). [Internet Available from: https://pubmed.ncbi.nlm.nih.gov/2869255/]. 1986; 1(8479):510–1. https://doi.org/10.1016/S0140- 6736(86)92979-X DOI: https://doi.org/10.1016/S0140-6736(86)92979-X

Bahekar S, Kale R, Nagpure S. A Review on Medicinal Plants Used in Scorpion Bite Treatment in India. Mintage J Pharm Med Sci. 2012; 1(1):1–6.

Bramhashankar, editor. Yogratnakar. Varanasi: Chaukhambha Prakashan. 2015. 473 p.

Tiwari AK, Deshpande SB. Toxicity of scorpion (Buthus tamulus) venom in mammals is influenced by the age and species. Toxicon. 1993; 31(12):1619– 22. https://doi.org/10.1016/0041-0101(93)90346-K DOI: https://doi.org/10.1016/0041-0101(93)90346-K

Gupta BD, Parakh M, Purohit A. Management of Scorpion Sting: Prazosin or Dobutamine. J Trop Pediatr. [Internet Available from: https://academic. oup.com/tropej/article/56/2/115/1729572]. 2010; 56(2):115–8. https://doi.org/10.1093/tropej/fmp070 DOI: https://doi.org/10.1093/tropej/fmp070

Sushruta. Sushrut samhita. first. Ambikadatta Shastri, editor. Varanasi: Chaukhmbha sanskrit sansthan. 2013. 8000 p.

Tripathi: Sharandhara Samhita of Pa - Google Scholar [Internet]. [cited 2022 Jan 19]. Available from: https:// scholar.google.com/scholar?cluster=7973699849245 999797&hl=en&as_sdt=2005&sciodt=0,5

Patil S, Chaudhary AK. Topical dosages forms. 2015; 2015(4):12–9.

Lee H, Song Y, Park YH, Uddin MS, Park JB. Evaluation of the Effects of Cuminum cyminum on Cellular Viability, Osteogenic Differentiation and Mineralization of Human Bone Marrow-Derived Stem Cells. Medicina (B Aires). [Internet Available from: /pmc/articles/PMC7823674/]. 2021; 57(1):1– 12. https://doi.org/10.3390/medicina57010038 DOI: https://doi.org/10.3390/medicina57010038