Toxicity Status of Nano Powder of Stem Bark of Bauhinia Variegata Linn. on Experimental Animals

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Authors

  • Prachi Vishwakarma
     Department of Kayachikitsa, Parul Institute of Ayurveda, Parul University, Vadodara - 391760, Gujarat. ,IN
  • Shailesh V. Deshpande
     Department of Kayachikitsa, Parul Institute of Ayurveda, Parul University, Vadodara - 391760, Gujarat. ,IN
  • Snigdha Das Mandal
     Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391760, Gujarat. ,IN

DOI:

https://doi.org/10.18311/jnr/2023/29566

Keywords:

Bauhinia variegata Linn., Liver Toxicity, Medicinal Plant, Safety
Acute Toxicity Study of Bauhinia Variegata Linn.

Abstract

The assumption that medicinal plants are less toxic or cause fewer adverse effects due to their natural composition is debatable. Hence, this study was conducted to evaluate the safety and toxicity of Nano Kanchanara stem bark powder (NKSP) on liver function. The oral acute toxicity of NKSP was conducted in accordance with OECD Guidelines 423 and was carried out with six (6) female Wistar albino rats, divided into two groups of three rats each. Test rats were orally administered a single dose of 2000 mg/kg of NKSP and were observed for changes in behavior and mortality for the next 14 days, while the Control Group was given feed and water ad libitum. The data obtained from the oral acute toxicity study indicated that there were non-significant (P<1.000) decreases in body weight of rats in the treatment groups of NKSP at 2000 mg/kg. There were no elevations in specific liver function enzymes, whereas there were increases in serum SGOT, SGPT, and albumin levels. Plasma total proteins and globulin, total bilirubin and serum creatinine were within the normal range. Albeit, hydropic changes and steatosis in liver lesions at NKSP 2000 mg/kg. The study suggests that oral administration of NKSP is safer at dose levels less than 2000 mg/kg/day.

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Published

2023-03-23

How to Cite

Vishwakarma, P., Deshpande, S. V., & Mandal, S. D. (2023). Toxicity Status of Nano Powder of Stem Bark of <i>Bauhinia Variegata</i> Linn. on Experimental Animals. Journal of Natural Remedies, 23(1), 263–270. https://doi.org/10.18311/jnr/2023/29566

Issue

Volume 23, Issue 1, January 2023

Section

Short Communication

License

Copyright (c) 2023 Prachi Vishwakarma, Prachi Vishwakarma

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Crossref
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Europe PMC
Received 2022-02-14
Accepted 2022-09-08
Published 2023-03-23

 

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