Evaluation of the Antioxidant, Antihyperglycemic and Hypolipidemic Potential of Alstonia scholaris Leaves Extracts in Streptozotocin-Induced Diabetic Rats

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Authors

  • Sonam Mishra
     Department of Pharmacology, LM College of Pharmacy, Gujarat Technological University, Ahmedabad - 380009, Gujarat ,IN
  • Jayesh Beladiya
     Department of Pharmacology, LM College of Pharmacy, Gujarat Technological University, Ahmedabad - 380009, Gujarat ,IN
  • Anita Mehta
     Department of Pharmacology, Anand Pharmacy College, Gujarat Technological University, Anand - 388001, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2023/31110

Keywords:

Alstonia scholaris, Anti-hyperglycemia, Antioxidant, Hypolipidemia, Streptozotocin

Abstract

The evergreen tree Alstonia scholaris (L) R. Br. (Family: Apocynaceae) is native to Australasia, southern China and the tropics of Asia. Despite its importance as a medicinal plant, little is known about its potential role in complementing standard methods of treating diabetes and its associated consequences. Therefore, the present study scientifically investigated extracts from the leaves of A. scholaris for their antioxidant (in vitro), anti-diabetic, and hypolipidemic effects in rats with type 2 diabetes mellitus. Male Wistar rats were administered streptozotocin (45 mg/kg, i.p.) and fed a high-fat diet to induce type 2 diabetes mellitus. They were treated with 400 mg/kg of an ethyl acetate (EAEAS) and ethanolic (EAAS) extract of A. scholaris leaves after complications persisted. Typical drugs were metformin (200 mg/kg) and canagliflozin (10 mg/kg). In the end, blood was drawn to determine various biochemical parameters such as fasting blood sugar, lipid profile and markers of heart, liver and kidney damage. In addition, the rat’s weight, urinary glucose concentration, urine volume, blood pressure, Electrocardiogram (ECG), and antioxidant potential of EEAS were measured. The pancreas, heart, kidneys, and liver were all subjected to histopathological analysis. A wide range of biochemical and physiological markers, including blood and urine glucose, lipid profile, markers of heart, kidney and liver damage, antioxidant levels and blood pressure, showed significant improvement in response to EEAS. Histopathology illustrates the reverse modulation in heart, kidney, and liver tissue compared to disease control. Based on the data obtained, the EAEAS achieved is far inferior to that required to treat diabetes mellitus. In summary, this present study demonstrates that EEAS (400 mg/kg) can lower blood sugar levels, fight free radicals, and lower bad cholesterol levels in rats with diabetes and complications. Further investigations can be undertaken to explore its mechanism of action at the molecular level.

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Published

2023-05-23

How to Cite

Mishra, S., Beladiya, J., & Mehta, A. (2023). Evaluation of the Antioxidant, Antihyperglycemic and Hypolipidemic Potential of <i>Alstonia scholaris</i> Leaves Extracts in Streptozotocin-Induced Diabetic Rats. Journal of Natural Remedies, 23(2), 499–511. https://doi.org/10.18311/jnr/2023/31110

Issue

Volume 23, Issue 2, April 2023

Section

Research Articles

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Copyright (c) 2022 Sonam Mishra

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2022-08-27
Accepted 2023-02-02
Published 2023-05-23

 

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