Anti-obesity and Antihyperlipidemic Activity of Ougeinia oojeinensis (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals

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Authors

  • K. Jagadeeshwar
     KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh ,IN
  • R. Subhakara Raju
     KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, ,IN
  • G. Chakravarthi
     KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh ,IN
  • A. Rajasekhar Reddy
     Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra ,IN
  • G. S. N. Koteswara Rao
     Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra ,IN
  • Narender Malothu
     KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh ,IN

DOI:

https://doi.org/10.18311/jnr/2023/32197

Keywords:

Antihyperlipidemic Anti-Obesity, Antioxidant, Lipid Profile, O. oojeinensis

Abstract

The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to produce the extracts. Wistar rats were subjected to a high-fat diet for 40 days to induce obesity. Along with the high-fat diet, a standard drug Orlistat 50 mg/kg and various extracts of O. oojeinensis at 100 mg/kg and 200 mg/kg were administered for 40 days. The key markers like lipid profiles, SGOT, SGPT, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, and weight of the organs were assessed. The anti-antioxidant properties like TBARS, GSH, GR, Gpx, SOD, and CAT were also estimated. The results revealed that O. oojeinensis with the doses 100 and 200 mg/kg showed significant Anti obese and hypolipidemic effects in rats fed with a high-fat diet.

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Author Biographies

K. Jagadeeshwar, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh

Ph.D. Scholar at K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502

R. Subhakara Raju, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh,

Professor, Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502

G. Chakravarthi, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh

Professor & HOD, Department of Pharmacognosy and Phytochemistry,

KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur,

Andhra Pradesh, India-522502

A. Rajasekhar Reddy, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra

Assistant Professor, Department Pharmaceutical Chemistry,

2Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s

NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai- 400056, India

 

G. S. N. Koteswara Rao, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra

Professor, at Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India

 

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Published

2023-06-13

How to Cite

Jagadeeshwar, K., Subhakara Raju, R., Chakravarthi, G., Rajasekhar Reddy, A., Koteswara Rao, G. S. N., & Malothu, N. (2023). Anti-obesity and Antihyperlipidemic Activity of <i>Ougeinia oojeinensis</i> (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals. Journal of Natural Remedies, 23(2), 545–554. https://doi.org/10.18311/jnr/2023/32197

Issue

Volume 23, Issue 2, April 2023

Section

Research Articles

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Copyright (c) 2023 K. Jagadeeshwar, R. Subhakara Raju, G. Chakravarthi, A. Rajasekhar Reddy, G. S. N. Koteswara Rao, Narender Malothu (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2022-12-19
Accepted 2023-04-24
Published 2023-06-13

 

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