Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of Elaeocarpus angustifolius Blume Leaves in Albino Wistar Rats

Abstract

Backgrounds: Hyperlipidemia is traditionally defined as conditions in which the concentration of cholesterol or triglyceride- carryingnlipoproteins in plasma exceeds an arbitrary normal limit. Elaeocarpus angustifolius Blume (Elaeocarpus ganitrus) is an average-sized evergreen tree with a various biological activity. The present study aimed to evaluate the antihyperlipidemic activity of ethanolic extract of E. angustifolius Blume leaves in albino Wistar rats. Materials and Methodology: The investigation was intended to scrutinize the anti-hyperlipidemic activity of extract which is ethanolic of EAB in high-fat fructose-fed hyperlipidemic rats. The EEEAB was managed at an amount level of 125, 250, and 500mg/kg p.o for 21 days in hyperlipidemic rats and atorvastatin was set as standard control. At the end of the 21 days, samples of blood were poised by the orbital retro and the profile of lipids was determined. For antioxidant activity in vitro of EEEAB was judged by using Hydrogen peroxide (H₂O₂) radical scavenging analysis. Result: The high-fat fructose diet-treated group exhibited hyperlipidemia with increased lipid concentrations along with an increase in body weight and downfall in temperature in contrast to the group regarded as control. EEEAB showed a decrease in the lipid levels (p<0.001, p<0.01, p<0.05) in a dose dose-dependent manner in treated rats and the HDL ratio improved after administration with EEEAB. For the in vitro study, the IC₅₀ worth of EEEAB was calculated to be 22μg/ml. Conclusion: The complete experimental outcomes suggested that the pharmacological operative phytoconstituent for instance flavonoids present in the EEEAB exhibited significant antihyperlipidemic activity on hyperlipidemic rats.