A Comparative Clinical Study on Agnikarma along with Panchatikta Guggulu in the Management of Janu Sandhigatvata (Osteoarthritis of Knee Joint)
DOI:
https://doi.org/10.18311/jnr/2024/32521Keywords:
Agnikarma, Osteoarthritis, Panchadhatu Shalaka, Panchatikta Guggulu, SandhigatavataAbstract
Background: Osteoarthritis is characterized by a slow and progressive deterioration of articular cartilage. It is a condition involving the breakdown of the protective cartilage covering the ends of the bones where two bones meet to form a joint. The aim was to evaluate the efficacy of Agnikarma with Panchatikta Guggulu in the management of Janu Sandhigatavata (osteoarthritis of knee joint). A total of 61 patients of Sandhigatavata (osteoarthritis of knee joint) were selected and randomly allocated into two groups, among them 57 were completed and 4 patients dropped out. In group A (n = 29), Agnikarma was done with Panchadhatu Shalaka and Panchatikta Guggulu orally given with lukewarm water after the meal. In group B (n = 28), Agnikarma was done with Panchadhatu Shalaka and a placebo capsule has orally given with lukewarm water after the meal. group‑A provided 70.35% relief in pain while group‑B provided 61.85% relief. Relief from crepitus was observed in 5.55% of patients of group‑A, while 1.92% of patients of group‑B. Both groups provided 68.57% relief in stiffness. There was a statistically insignificant difference between both groups. Group A shows better result in pain relief than group B. Agnikarma with Panchatikta Guggulu is more effective than Agnikarma alone in the management of Janu Sandhigatavata.
Downloads
Metrics
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Manisha M. Kapadiya, T. S. Dudhamal (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-02-20
Published 2024-06-30
References
Ranjan KC, et al. Chronic alcohol consumption induces osteoarthritis - like pathological changes in an experimental mouse model. Arthritis Rheumatol. 2015; 67(6):1678-80. https://doi.org/10.1002/art.39090 PMid:25708245 PMCid: PMC4823794.
Hinman RS, et al. Hip muscle weakness in individuals with medial knee osteoarthritis. Arthritis Care Res (Hoboken). 2010; 62(8):1190-3. https://doi.org/10.1002/acr.20199 PMid:20704005.
Golwala. Medicine for students. Rheumatology; 25th ed. 2017; 21(10):1032.
Deshpande BR, et al. Number of persons with symptomatic knee osteoarthritis in the U.S: impact of race and ethnicity, age, sex and obesity. Arthritis Care and Research. 2016; 68(12):1743-50. https://doi.org/10.1002/acr.22897 PMid:27014966 PMCid: PMC5319385.
Tangtrakulwanich B, Suwanno P. Epidemiology and risk factors of patellofemoral osteoarthritis in adults: a population-based study in Southern Thailand. J Med Assoc Thai. 2012; 95(8):1048-52.
Green GA, Understanding NSAIDS: from Aspirin to COX-2 clinical cornerstone. 2001; 3 (5):50- 60. https://doi.org/10.1016/S1098-3597(01)90069-9 PMid:11464731.
Mody G, Woolf A. A report on global burden musculoskeletal disorders. Business Briefing of Pharmacotherapy Association. 2003.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004403 Accessed on 4/7/2019.
Acharya JT. Editor. Charaka Samhita, Sutra Sthana, Mahachatushpada, 10/18, Reprint, Chaukhambha Prakashan, Varanasi, 2013.
Acharya JT. Editor. Charaka Samhita, Sutra Sthana, Mahachatushpada, 10/10, Reprint, Chaukhambha Prakashan, Varanasi, 2013.
Srikantha Murthy KR. Editor. Susruta Samhita, Sushruta, Sutra Sthana, AgnikarmavidhiAdhyayam. Reprint, Chaukhambha Orientalia, Varanasi. 2008; 12(3):1.
Sastri A. Editor. Bhaishajya Ratnavali, Kushtaroga Adhikara. Reprint, Choukhambha Surabharati Prakashana Varanasi. 2016; 54:233-6.
Sharma PV. Editor. Chakradatta, Kushtaroga Adhikara. 1st Edition, Swami Sayaramdasramprakash Trust, Jaipur. 1993; 48:116-9.
Shastri K, Editor. Charaka Samhita Chikitsa Sthana, Vatavyadhichikitsa. Varanasi: Chaukhambha Sanskrit Samsthan. 2004; 28/37(2):783.
Sharma AR, Sushruta Samhita, Nidana Sthana, Vatavyadhinidana. Editor. Varanasi: Chaukhambha Sanskrit Samsthan. 2004; 1/28(1):458.
Upadhyaya Y. Editor. Madhava Nidanam, Vatavyadhinidana. 32nd ed. Varanasi: Chaukhambha Sanskrit Samsthan. 2002; 22/21(1):463.
Gupta PD. Agnikarma technological innovations (treatment by therapeutic burning); 1st Edition, Prabha Publications, Nagpur, 1992.
Ambikadat S. Hindi Commentory Bhaisjyaratnawali, Kustharogachikitsa, Shloka 54/233-236. 19th edition. p. 904.
Kraus VB, et al. Call for standardised definition of osteoarthritis and risk stratification for clinical trials and clinical use, osteoarthritis cartilage. 2015; 23(8):1233-41. https://doi.org/10.1016/j.joca.2015.03.036 PMid:25865392 PMCid: PMC4516635.
Kraus VB, et al. Call for standardised definition of osteoarthritis and risk stratification for clinical trials and clinical use, osteoarthritis cartilage. 2015; 23(8):1233-41. https://doi.org/10.1016/j.joca.2015.03.036 PMid:25865392 PMCid: PMC4516635.
Roman-Blas JA, et al. Review osteoarthritis associated with estrogen deficiency, Arthritis Research and Therapy. 2009; 11(5):1-41. https://doi.org/10.1186/ar2791 PMid:19804619 PMCid: PMC2787275.
Mahajan A, Tandon V, Verma S, Sharma S. Osteoarthritis and menopause. J Indian Rheumatol Assoc. 2005; 13:215.
Doherty M, Jones A, Cawston T. Osteoarthritis. In: Oxford Textbook of Rheumatology. 3rd ed. (Eds.: Isenberg DA, et al) Oxford: Oxford University Press; 2004; 1091118.
Spector TD, MacGregor AJ. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage. 2004; 12(Suppl A):S39-44. https://doi.org/1016/j.joca.2003.09.005. PMID: 14698640.
Umesh Sehgai, et al. Role of agnikarma and ajmodadi vati in the management of sandhigatavata W.S.R. to cervicle spondylitis; AYU. 2009; 30(3):345-9.
Sharma AV, et al. Clinical study of Agnikarma and Panchatikta guggulu in the management of sandhivata (osteoarthritis of the knee joint), AYU. 2016; 37(1):38-44 https://doi.org/10.4103/ayu.AYU_103_14 PMid: 28827954 PMCid: PMC5541466.
Chaturvedi S, et al. Applied approach of agnikarma therapy. Journal of Biological and Scientific Opinion. 2014; 2(1):107-9. https://doi.org/10.7897/2321-6328.02125
Chaturvedi S, et al. Applied approach of Agnikarma therapy. Journal of Biological and Scientific Opinion. 2014; 2(1):107-9. https://doi.org/10.7897/2321-6328.02125
Surendra K, Gopesh M. Pharmacodynamics of Panchatikta guggulughritain asthimajjagatavata with special reference to avascular necrosis of femoral head. World J PharmSci. 2022; 10(08):16-9. https://doi.org/10.54037/WJPS.2022.100801
Sharma AV, et al. Clinical study of Agnikarma and Panchatikta guggulu in the management of sandhivata (osteoarthritis of the knee joint), AYU. 2016; 37(1):38-44. https://doi.org/10.4103/ayu.AYU_103_14 PMid:28827954 PMCid: PMC5541466.