In Silico Computational Analysis of Citrus aurantium of Thurunji manapagu in Inhibiting the Receptor Target of Angiotensin-converting Enzyme Against Uratha Pitha Vatham (Hypertension)

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Authors

  • Radha Sudalaimani
     Siddha Clinical Research Unit, Tirupati, Central Council for Research in Siddha (Under Ministry of AYUSH ) SVIMS Campus, Alipiri Road, Tirupati – 517507, Andhra Pradesh, India ,IN
  • Swathi Thangapandiyan
     Siddha Clinical Research Unit, Tirupati, Central Council for Research in Siddha (Under Ministry of AYUSH ) SVIMS Campus, Alipiri Road, Tirupati – 517507, Andhra Pradesh, India ,IN
  • Mariappan Andi
     Department of Gunapadam, National Institute of Siddha (An Autonomous body under the Ministry of AYUSH), Tambaram Sanatorium, Chennai – 600047, Tamil Nadu, India ,IN
  • Sivakumar Shantiarappa Udayar
     Department of Gunapadam, National Institute of Siddha (An Autonomous body under the Ministry of AYUSH), Tambaram Sanatorium, Chennai – 600047, Tamil Nadu, India ,IN
  • Meenakumari Ramasamy
     National Institute of Siddha (An Autonomous Body Under the Ministry of AYUSH), Tambaram Sanatorium, Chennai – 600047, Tamil Nadu, India ,IN

DOI:

https://doi.org/10.18311/jnr/2023/32916

Keywords:

Antihypertensive, Citrus aurantium, Molecular Docking, Siddha Medicine, Uratha Pitha Vatham

Abstract

Citrus aurantium (Thurunji) is a tree cultivated in various parts of the world. The fruit pulp is used to make juices, marmalade and pickles. It is commonly used by tribes to treat digestive disorders, constipation, heaviness in the chest, prolapse of the uterus, anorexia, chest pain, cold, and cough. In the Siddha system of medicine, Citrus aurantium fruit pulp is used to prepare a formulation, syrup in consistency named Thurunji manapaagu indicated for diseases due to deranged pitha humor. According to the Siddha system of medicine Hypertension termed Uratha Pitha Vatham is an ailment that occurs due to an elevated pitham. Considering the facts an attempt of in silico docking study was done with the selected phytochemicals such as Linalool, Apigenin, Ichangin, Kaempferol, Luteolin, Limonin, Limonene, Myrcene, Diosmetin and Tangeretin of Citrus aurantium against Angiotensin Converting Enzyme (ACE) and the results are detailed in this article.

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Published

2023-11-03

How to Cite

Sudalaimani, R., Thangapandiyan, S., Andi, M., Udayar, S. S., & Ramasamy, M. (2023). <i>In Silico</i> Computational Analysis of <i>Citrus aurantium</i> of <i>Thurunji manapagu</i> in Inhibiting the Receptor Target of Angiotensin-converting Enzyme Against <i>Uratha Pitha Vatham</i> (Hypertension). Journal of Natural Remedies, 23(4), 1411–1424. https://doi.org/10.18311/jnr/2023/32916

Issue

Volume 23 Issue 4 October 2023

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Research Articles

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Copyright (c) 2022 Radha Sudalaimani, Swathi Thangapandiyan, Mariappan Andi, Sivakumar Shantiarappa Udayar, Meenakumari Ramasamy (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-02-07
Accepted 2023-09-20
Published 2023-11-03

 

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