Quercetin Mitigates Diabetic Nephropathy in Rats via Keap1/Nrf2/HO-1 Signaling Pathway

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Authors

  • Ankita Desai
     Faculty of Pharmacy, Dharamsinh Desai University, Nadiad - 387001, Gujarat ,IN
  • Hital Shah
     Department of Pharmacology, Anand Pharmacy College, Anand - 388001, Gujarat ,IN
  • Anjali Patel
     Department of Pharmacology, Anand Pharmacy College, Anand - 388001, Gujarat ,IN
  • Tejal R. Gandhi
     Department of Pharmacology, Anand Pharmacy College, Anand - 388001, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2023/33313

Keywords:

Caspase-3, Diabetic Nephropathy, HO-1, Nrf2, NFκB, Oxidative Stress, Quercetin

Abstract

A severe diabetic complication, diabetic nephropathy, progresses to terminal kidney disease. A chronic hyperglycemia-related excess of reactive oxygen species results in the advancement of diabetes complications. Through streptozotocin-induced diabetic nephropathy in rats, the present study investigated Quercetin’s renoprotective effect by upregulating nuclear factor-erythroid-related factor 2 (Nrf2) to cope with oxidative stress. During eight weeks study, daily food-water and weekly body weight were evaluated while biochemical, antioxidant parameters and genetic expression (Nrf2, Hemeoxygenease-1, Nuclear factor kappa B, Interlukin-6, and Caspase-3) were assessed at the end. The outcomes were interpreted using ANOVA, and the significance was determined using Dunnett’s test. Quercetin treatment for eight weeks significantly controlled hyperglycemia, dyslipidemia, and downregulated inflammatory activators NFκB, IL-6, and Caspase-3. The significant upregulation of Nrf2 gene expression reduced oxidative damage by promoting Antioxidant response elements and initiating downstream cascade (HO-1 and antioxidant enzymes). The results are supported by histopathology. Experimental evidence suggests that Quercetin can fight metabolic disorders and their related microvascular diseases by activating Nrf2.

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Published

2023-07-03

How to Cite

Desai, A., Shah, H., Patel, A., & Gandhi, T. R. (2023). Quercetin Mitigates Diabetic Nephropathy in Rats via Keap1/Nrf2/HO-1 Signaling Pathway. Journal of Natural Remedies, 23(3), 1009–1024. https://doi.org/10.18311/jnr/2023/33313

Issue

Volume 23 Issue 3 July 2023

Section

Research Articles

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Copyright (c) 2022 Ankita Desai, Hital Shah, Anjali Patel, Tejal R. Gandhi (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-03-17
Accepted 2023-05-23
Published 2023-07-03

 

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