Comparative Physicochemical Evaluation and Acute Toxicity Study of Crude and Processed (Detoxified) Samples of Saqmunia (Convolvulus scammonia L.) in Albino Wistar Rats

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Authors

  • Huzaifa Ansari
     Mohammadia Tibbiya College and Assayer Hospital, Maharashtra University of Health Sciences, Nashik – 422004, Maharashtra, India ,IN
  • Athar Parvez Ansari
     Regional Research Institute of Unani Medicine, Chennai (NABH Accredited), Central Council for Research in Unani Medicine, Ministry of Ayush, Government of India, Chennai – 600013, Tamil Nadu, India ,IN
  • Pankaj Goswami
     Division of Veterinary Pathology, Sher-e-Kashmir University of Agriculture Sciences and Technology of Kashmir, R. S. Pura, Jammu, India ,IN
  • Ifra Qayoom
     Kashmir Tibbia College, Hospital and Research Center, University of Kashmir, Shilwat – 193501, Jammu and Kashmir, India ,IN
  • Abdul Hasib
     Regional Research Institute of Unani Medicine, Srinagar (NABH Accredited), Central Council for Research in Unani Medicine, Ministry of Ayush, Government of India, India ,IN
  • Bazilah Majeed Reshi
     Regional Research Institute of Unani Medicine, Srinagar (NABH Accredited), Central Council for Research in Unani Medicine, Ministry of Ayush, Government of India, India ,IN
  • Seema Akbar
     Regional Research Institute of Unani Medicine, Srinagar (NABH Accredited), Central Council for Research in Unani Medicine, Ministry of Ayush, Government of India, India ,IN

DOI:

https://doi.org/10.18311/jnr/2023/33454

Keywords:

Acute Toxicity, Convolvulus scammonia, Detoxification, Physicochemical Standardization, Saqmunia

Abstract

Background and Objectives: Tadbīr va Islāh-i-Adwiya (detoxification/rectification of drugs) is a distinctive concept of Unani medicine in which drugs that are toxic by nature are detoxified before being administered to the human body. In Unani medicine, the resin called Saqmunia which is a derivative of the rhizome of Convolvulus scammonia, is used for therapeutic purposes. So far, limited research studies have been carried out to appraise the age-old concept of detoxification of Unani drugs. Therefore, the present study was designed to explore the physicochemical characteristics and acute toxicity of crude and detoxified samples of Saqmunia in albino Wistar rats. Methods: Saqmunia was detoxified through the tashwiya (roasting) method using apple and cow dung cakes. The physicochemical standardization includes moisture content, different ash values, extractive values; pH, fluorescence analysis, and TLC were performed. The acute toxicity study of both samples of Saqmunia was carried out at 300 and 2000 mg/kg dose levels in female albino Wistar rats. The data were analyzed using Oneway ANOVA followed by Dunnett’s comparison test. Results: The findings of the physicochemical standardization of crude and detoxified Saqmunia were found to be within an accepted range. The acute toxicity study has shown that the non-detoxified form of the test drug produced maximum toxicities, even causing death in rats. The LD50 of crude and detoxified Saqmunia was found to be 1000 mg and > 2000 mg/kg, respectively, in rats. Conclusions: The present study has suggested that Saqmunia used in this study was of good quality, and the physicochemical constants found in this study may be taken as a reference for future studies. Moreover, the acute toxicity study validates the Unani concept of detoxification of drugs, as is evident from the minimal toxic effects found in the detoxified sample of Saqmunia as compared to the crude sample in rats.

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Published

2023-10-31

How to Cite

Ansari, H., Ansari, A. P., Goswami, P., Qayoom, I., Hasib, A., Reshi, B. M., & Akbar, S. (2023). Comparative Physicochemical Evaluation and Acute Toxicity Study of Crude and Processed (Detoxified) Samples of <i>Saqmunia</i> (<i>Convolvulus scammonia</i> L.) in Albino Wistar Rats. Journal of Natural Remedies, 23(4), 1461–1474. https://doi.org/10.18311/jnr/2023/33454

Issue

Volume 23 Issue 4 October 2023

Section

Research Articles

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Copyright (c) 2023 Huzaifa Ansari, Athar Parvez Ansari, Pankaj Goswami, Ifra Qayoom, Abdul Hasib, Bazilah Majeed Reshi, Seema Akbar (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-04-01
Accepted 2023-08-21
Published 2023-10-31

 

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