Hepatoprotective Efficacy of Phytochemically Screened Nyctanthes arbor-tristis

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Authors

  • Ajay Sharma
     Mahakal Institute of Pharmaceutical Studies, Ujjain – 456664, Madhya Pradesh ,IN
  • Shailesh Kewatkar
     Rajarshi Shahu College of Pharmacy, Buldana – 443001, Maharashtra ,IN
  • Jeevan S. Dhumal
     Rajmata Jijau Shikshan Prasarak Mandal’s College of Pharmacy, Pune – 412105, Maharashtra ,IN
  • Gaurav Jain
     IES Institute of Pharmacy, IES University, Bhopal – 462044, Madhya Pradesh ,IN
  • Akanksha Jagwani
     LNCT School of Pharmacy, LNCT Vidhyapeeth University, Indore – 452016, Madhya Pradesh ,IN
  • Amit Joshi
     Lakshmi Narain College of Pharmacy, Bhopal – 462022, Madhya Pradesh ,IN
  • Har Goving Garg
     Lakshmi Narain College of Pharmacy, Bhopal – 462022, Madhya Pradesh ,IN

DOI:

https://doi.org/10.18311/jnr/2023/33791

Keywords:

Hepatoprotective Efficacy, Nyctanthes arbor-tristis, Phytochemical Screening

Abstract

The Oleaceae plant Nyctanthes arbor-tristis Linnaeus is used in Ayurveda medicine as a laxative, diuretic, and for the treatment of a variety of painful conditions including sciatica, arthritis, and fever. This study aimed to determine whether or not extracts of Nyctanthes arbor-tristis leaves, either in alcohol or water, might prevent liver damage caused by carbon tetrachloride in rats. Administration of alcoholic and aqueous extracts of the leaves of Nyctanthes arbor-tristis protects the liver against the toxicity of carbon tetrachloride by lowering the high levels of serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, and serum bilirubin (total and direct). Both the alcoholic and aqueous extracts demonstrated hepatoprotective efficacy at a dosage of 500 mg/kg body weight by significantly reducing the high levels of biochemical markers. Liver histopathology studies corroborated the extracts’ potential to restore damaged hepatocytes.

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Published

2023-11-09

How to Cite

Sharma, A., Kewatkar, S., Dhumal, J. S., Jain, G., Jagwani, A., Joshi, A., & Garg, H. G. (2023). Hepatoprotective Efficacy of Phytochemically Screened <i>Nyctanthes arbor-tristis</i>. Journal of Natural Remedies, 23(4), 1491–1508. https://doi.org/10.18311/jnr/2023/33791

Issue

Volume 23 Issue 4 October 2023

Section

Research Articles

License

Copyright (c) 2022 Ajay Sharma, Shailesh Kewatkar, Jeevan S. Dhumal, Gaurav Jain, Akanksha Jagwani, Amit Joshi, Har Goving Garg (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-05-14
Accepted 2023-07-14
Published 2023-11-09

 

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