Androgenic Activity of the Total Alkaloid Fraction of <I>Alangium salviifolium</I> (Linn.F)

V. Murugan; S. Gulhana; S. Badami; M. Ramanathan; B. Suresh

doi:10.18311/jnr/2002/347

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Authors

V. Murugan
,IN
S. Gulhana
,IN
S. Badami
,IN
M. Ramanathan
,IN
B. Suresh
,IN

DOI:

https://doi.org/10.18311/jnr/2002/347

Keywords:

Alangium salviifolium, Total Alkaloid Fraction, Androgenic Activity.

Therapeutic Drug Monitoring

Abstract

Objective: To perform the androgenic and anti-androgenic activity of the total alkaloid fraction of Alangium salviifolium (Family: Alangiaceae). Materials and methods: The total alkaloid fraction of the methanolic extract of stem bark of Alangium salviifolium was used for the experiment. Immature male albino rats received orally a dose of 10 mg and 20 mg/kg body weight of the fraction for 7 days. The weight of the reproductive organs of the treated rats was measured on the eighth day of the treatment and histometric measurements were carried out. Results: A significant increase in the weight of testis, seminal vesicles, ventral prostate and epididymis was observed in the treated rats. Conclusion: The results suggest the androgenic behaviour of the total alkaloid fraction.