The Role of Curcumin in Gastric Carcinoma by Modulating the Immune System and its SAR
Authors
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Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida – 201306, Uttar Pradesh ,IN
Akshay Kumar -
Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida – 201306, Uttar Pradesh ,INChandana Majee
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Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida – 201306, Uttar Pradesh ,INRupa Mazumder
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Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida – 201306, Uttar Pradesh ,INRuchi Sharma
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Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida – 201306, Uttar Pradesh ,INAvijit Mazumder
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Department of Biotechnology, Noida Institute of Engineering and Technology, Greater Noida – 201306, Uttar Pradesh ,INRashmi Mishra
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Lovely Professional University, Jalandhar - Delhi, Grand Trunk Rd, Phagwara – 144001, Punjab ,INPankaj Wadhwa
DOI:
https://doi.org/10.18311/jnr/2024/34910Keywords:
Curcumin, Immune-Modulation, Gastric Carcinoma, Structure-activity Relationship, Signalling PathwaysAbstract
The second most prevalent cancer in the world and the fifth most common malignant tumour is gastric carcinoma. It is thought that several factors, including genetics, epigenetics, and environmental impacts, contribute to the development of gastric cancer. One of the main pathogenic variables associated with stomach cancer risk has been identified as inflammation. There are currently few methods to treat the gastric carcinoma. Therefore, an alternative plan is urgently needed. Explaining the importance of curcumin derived from Curcuma longa Linn. in stomach cancer is the goal of this review. According to recent research, Curcumin (CUR) has a great effect against stomach mucosal injury brought on by non-steroidal anti-inflammatory medicines, gastric mucosal injury in rats, stress haemorrhage, and Helicobacter pylori infection. In this review article, we have discussed the chemistry of CUR, the role of CUR in immunomodulation, and gastric cancer. We have also highlighted the various signalling pathway of gastric cancer where CUR work. By controlling miRNAs on gastric cancer and other relevant signal pathways, CUR exhibits notable anti-inflammatory and anti-cancer properties. In future there are more research work will be done on CUR.
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Copyright (c) 2024 Akshay Kumar, Chandana Majee, Rupa Mazumder, Ruchi Sharma, Avijit Mazumder, Rashmi Mishra, Pankaj Wadhwa (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2023-09-20
Published 2024-01-01
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