Sinapis alba ln Status Epilepticus: A Preclinical Study

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Authors

  • Gayatri R. Nayak
     Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN
  • Amrita Parida
     Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN
  • Shreya Hegde
     Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN
  • Smita Shenoy
    Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN ORCID logo https://orcid.org/0000-0002-7578-1855
  • K. G. Mohandas Rao
     Department of Basic Medical Sciences, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN
  • K. Shivakumar Reddy
     Centre for Molecular Neurosciences, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN
  • V. Manju
     Department of Paediatrics, Dr. T.M. A. Pai Rotary Hospital, Karkala, Manipal, Manipal Academy of Higher Education, Manipal - 576104, Karnataka ,IN

DOI:

https://doi.org/10.18311/jnr/2024/34983

Keywords:

Epilepsy, Seizures, Traditional Medicine, Yellow Mustard

Abstract

In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.

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Published

2024-02-01

How to Cite

Nayak, G. R., Parida, A., Hegde, S., Shenoy , S., Mohandas Rao, K. G., Shivakumar Reddy, K., & V. Manju. (2024). <i>Sinapis alba</i> ln Status Epilepticus: A Preclinical Study. Journal of Natural Remedies, 24(02), 311–322. https://doi.org/10.18311/jnr/2024/34983

Issue

Volume 24, Issue 2, February 2024

Section

Research Articles

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Copyright (c) 2024 Gayatri. R. Nayak, Amrita Parida, Shreya Hegde, Smita Shenoy , K. G. Mohandas Rao, K. Shivakumar Reddy, Manju. V (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-09-08
Accepted 2023-11-30
Published 2024-02-01

 

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