From a Global Perspective Towards an Integrated Approach for Ophitoxaemia

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Authors

  • Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty - 643001, Tamil Nadu ,IN
  • Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty - 643001, Tamil Nadu ,IN
  • Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Priyadarshini Nagar – 605006, Puducherry ,IN
  • Oncology Division, Clinical Trials R and D, Medical Writing, Mu Sigma Inc., Bangalore - 560066, Karnataka ,IN
  • Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty - 643001, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/jnr/2024/35905

Keywords:

Ayurveda, Integration, Limitations, Modern Medicine, Snakebite

Abstract

Ophitoxaemia is the medical term that describes an injury induced by a snake bite which can be fatal in the case of venomous snakes. Bleeding, allergic response, necrosis, and bradycardia are symptoms of venomous bite. Snake venom is from a complex mixture of proteins- enzymes, nonenzymatic polypeptide toxins, and nontoxic proteins. Based on the nature of the toxin and type of snake, the toxins are classified into neuro, cardio, and cytotoxins. This comparative study aims to explore and compare the practice of the traditional Ayurveda system and the modern system of medicine for snakebite management. By examining the existing literature and research on both systems, this article will provide insights into their efficacy, safety, and potential for integration.

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Published

2024-07-31

How to Cite

Navanita, S. K., Narayana Reddy Karri, V. V. S., Prakash Yoganandam, G., Shanker, K., & Vasanth Raj, P. (2024). From a Global Perspective Towards an Integrated Approach for Ophitoxaemia. Journal of Natural Remedies, 24(7), 1493–1498. https://doi.org/10.18311/jnr/2024/35905
Received 2023-12-15
Accepted 2024-06-25
Published 2024-07-31

 

References

Kasturiratne A, Wickremasinghe AR, de Silva N, Gunawardena NK, Pathmeswaran A, Premaratna R, et al. The global burden of snakebite: A literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med. 2008; 5(11):e218. https://doi.org/10.1371/journal.pmed.0050218 PMid:18986210 PMCid: PMC2577696 DOI: https://doi.org/10.1371/journal.pmed.0050218

Chippaux JP. Snake-bites: Appraisal of the global situation. Bull World Health Organ. 1998; 76:515-24.

World Health Organization (WHO). Snakebite envenoming. WHO Press. 2019. Available from: https://www.who.int/newsroom/fact-sheets/detail/snakebite-envenoming

Jaiswal YS, Williams LL. A glimpse of Ayurveda - The forgotten history and principles of Indian traditional medicine. J Tradit Complement Med. 2017; 7(1):50-3. https://doi.org/10.1016/j.jtcme.2016.02.002PMid:28053888 PMCid: PMC5198827 DOI: https://doi.org/10.1016/j.jtcme.2016.02.002

Hamza M, Knudsen C, Gnanathasan CA, Monteiro W, Lewin MR, Laustsen AH, et al. Clinical management of snakebite envenoming: Future perspectives. Toxicon: X. 2021; 11:100079. https://doi.org/10.1016/j.toxcx.2021.100079 PMid:34430847 PMCid: PMC8374517 DOI: https://doi.org/10.1016/j.toxcx.2021.100079

Pandey N, Sharma A, Kadu VA, Shankar G. Critical review to understand the twenty-four Ayurveda treatment modalities for the management of snake bite. J Indian Syst Med. 2022; 10(1):19-9. https://doi.org/10.4103/JISM.JISM_81_21 DOI: https://doi.org/10.4103/JISM.JISM_81_21

Gutierrez JM, Leon G, Lomonte B, Angulo Y. Antivenoms for snakebite envenomings. Inflamm Allergy Drug Targets. 2011; 10(5):369-80. https://doi.org/10.2174/187152811797200669 PMid:21745181 DOI: https://doi.org/10.2174/187152811797200669

Gutiérrez JM, Solano G, Pla D, Herrera M, Segura Á, Vargas M, et al. Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead. Toxins. 2017; 9(5):163. https://doi.org/10.3390/toxins9050163 PMid:28505100 PMCid: PMC5450711 DOI: https://doi.org/10.3390/toxins9050163

Whalen K. Pharmacology. 6th ed. Lippincott Illustrated Reviews; 2015. p. 644-6.

Roberts NLS, Johnson EK, Zeng SM, Hamilton EB, Abdoli A, Alahdab F, et al. Global mortality of snakebite envenoming between 1990 and 2019. Nat Commun. 2022; 13(1):6160. https://doi.org/10.1038/s41467-022-33627-9 DOI: https://doi.org/10.1038/s41467-022-33627-9

Vanuopadath M, Rajan K, Alangode A, Nair SS, Nair BG. The need for next-generation antivenom for snakebite envenomation in India. Toxins. 2023; 15(8):510. https://doi.org/10.2174/187152811797200669 PMid:21745181 DOI: https://doi.org/10.3390/toxins15080510

Ahmed S, Ahmed M, Nadeem A, Mahajan J, Choudhary A, Pal J. Emergency treatment of a snake bite: Pearls from literature. J Emerg Trauma Shock. 2008; 1(2):97-105. https://doi.org/10.4103/0974-2700.43190 PMid:19561988 PMCid: PMC2700615 DOI: https://doi.org/10.4103/0974-2700.43190

Fry B. Snakebite: When the human touch becomes a bad touch. Toxins. 2018; 10(4):170. https://doi.org/10.3390/toxins10040170. PMid:29690533 PMCid: PMC5923336 DOI: https://doi.org/10.3390/toxins10040170

Bénard-Valle M, Neri-Castro EE, Fry BG, Boyer L, Cochran C, Alam M, et al. Antivenom research and development. In: Fry BG, editor. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. New York: Oxford University Press; 2015. p. 61-72.

Boyer L, Alagón A, Fry BG, Jackson TNW, Sunagar K, Chippaux JP. Signs, symptoms and treatment of envenomation. In: Fry BG, editor. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. New York: Oxford University Press; 2015. p. 32-60.

Sutherland SK, Lovering KE. Antivenoms: use and adverse reactions over a 12-month period in Australia and Papua New Guinea. Med J Aust. 1979; 2(13):671-4. https://doi.org/10.5694/j.1326-5377.1979.tb104266.x PMid:530188 DOI: https://doi.org/10.5694/j.1326-5377.1979.tb104266.x

Sutherland SK. Acute untoward reactions to antivenoms. Med J Aust. 1977; 2(25):841-2. https://doi.org/10.5694/j.1326-5377.1977.tb99342.x DOI: https://doi.org/10.5694/j.1326-5377.1977.tb99342.x

Sutherland SK. Serum reactions. An analysis of commercial antivenoms and the possible role of anticomplementary activity in de-novo reactions to antivenoms and antitoxins. Med J Aust. 1977; 1:613-5. https://doi.org/10.5694/j.1326-5377.1977.tb130959.x PMid:327229 DOI: https://doi.org/10.5694/j.1326-5377.1977.tb130959.x

Malasit P, Warrell DA, Chanthavanich P, Viravan C, Mongkolsapaya J, Singhthong B, et al. Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites. British Medical Journal. 1986; 292(6512):17-20. https://doi.org/10.1136/bmj.292.6512.17 PMid:3080048 PMCid: PMC1338972 DOI: https://doi.org/10.1136/bmj.292.6512.17

de Silva HA, Pathmeswaran A, Ranasinha CD, Jayamanne S, Samarakoon SB, Hittharage A, et al. Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. PLoS Med. 2011; 8(5):e1000435. https://doi.org/10.1371/journal.pmed.1000435 PMid:21572992 PMCid: PMC3091849 DOI: https://doi.org/10.1371/journal.pmed.1000435

Moran NF, Newman WJ, Theakston RD, Warrell DA, Wilkinson D. High incidence of early anaphylactoid reaction to SAIMR polyvalent snake antivenom. Trans R Soc Trop Med Hyg. 1998; 92(1):69-70. https://doi.org/10.1016/S0035-9203(98)90959-2 PMid:9692158 DOI: https://doi.org/10.1016/S0035-9203(98)90959-2

Vongphoumy I, Chanthilat P, Vilayvong P, Blessmann J. Prospective, consecutive case series of 158 snakebite patients treated at Savannakhet provincial hospital, Lao People’s Democratic Republic with a high incidence of anaphylactic shock to horse derived F(ab’)2 antivenom. Toxicon. 2016; 117:13-21. https://doi.org/10.1016/j.toxicon.2016.03.011 PMid:26995210 DOI: https://doi.org/10.1016/j.toxicon.2016.03.011

León G, Herrera M, Segura Á, Villalta M, Vargas M, Gutiérrez JM. Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms. Toxicon. 2013; 76:63-76. https://doi.org/10.1016/j.toxicon.2013.09.010 PMid:24055551 DOI: https://doi.org/10.1016/j.toxicon.2013.09.010

Ryan NM, Downes M, Isbister GK. Clinical features of serum sickness after Australian snake antivenom. Toxicon. 2015; 108:181-3. https://doi.org/10.1016/j.toxicon.2015.10.012 PMid:26525657 DOI: https://doi.org/10.1016/j.toxicon.2015.10.012

Tritt A, Gabrielli S, Zahabi S, Clarke AE, Moisan J, Eisman H, et al. Short- and long-term management of cases of venom-induced anaphylaxis is suboptimal. Ann Allergy Asthma Immunol. 2018; 121(2):229-234.e1. https://doi.org/10.1016/j.anai.2018.04.006 PMid:29656144 DOI: https://doi.org/10.1016/j.anai.2018.04.006