Development and Characterisation of Curcuminoid Loaded Hydrogel for the Effective Treatment of Diabetic Retinopathy

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Authors

  • Durga Prasad Kondeti
     SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu ,IN
  • T. Sundarrajan
     Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36288

Keywords:

Curcuminoid, Diabetic Retinopathy, Dispersion, Hydrogel Formulation

Abstract

Background: The leading cause of vision loss in individuals with diabetes worldwide is diabetic retinopathy. A curcuminoid-loaded hydro gel has been proposed to improve solubility and ocular permeation. Aim: A gel-based formulation using gellan gum was hypothesised to enhance its bioavailability. The RP-HPLC analysis confirmed curcuminoid isolated from raw turmeric. Methods: By varying the gellan gum concentrations, three different formulations were developed. The developed curcuminoid-loaded gel formulation was further characterised by its FT-IR signature analysis, particle size, zeta potential, morphology and in-vitro release behaviour. Results: The signature analysis results indicate a drug’s signature in the formulation. The study revealed sphere-sized particles ranging from 6387±113 to 4595±184 nm with zeta potential ranging from -21 ±2.29 mV to -19.6 ±3.19 mV. A sustained release pattern was observed by the in-vitro release studies. The results of ex vivo corneal permeation studies indicate that the developed curcuminoid loaded hydrogel have some exposure to the posterior segment of the eye. Conclusion: To conclude the developed curcuminoid hydrogel may provide exposure to the posterior segment of the eye due to its significant corneal permeation property.

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Published

2024-07-31

How to Cite

Kondeti, D. P., & Sundarrajan, T. (2024). Development and Characterisation of Curcuminoid Loaded Hydrogel for the Effective Treatment of Diabetic Retinopathy. Journal of Natural Remedies, 24(7), 1537–1545. https://doi.org/10.18311/jnr/2024/36288

Issue

Volume 24, Issue 7, July 2024

Section

Research Articles

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Copyright (c) 2024 Durga Prasad Kondeti, T. Sundarrajan (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2024-01-17
Accepted 2024-06-24
Published 2024-07-31

 

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