Exploring the Anti-obesity Properties of Corn Silk Extract (CornFit®) in C57BL/6 Mice Induced with Obesity via a High-Fat Diet

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Authors

  • H. N. Shivaprasad
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • Gaurav Soni
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • Madhu Krishnamani
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • T. Sravani
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • Machiraju Garaga
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • D. Manohar
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36556

Keywords:

Anti-adipogenic, Inflammation, Lipogenic, Metabolic Health, Zea mays

Abstract

Objective: The impact of CornFit®, an extract derived from corn silk was assessed on obesity-induced mice subjected to a High-Fat Diet (HFD). Methods: C57BL/6 mice were assigned to seven groups: normal control, HFD control, reference standard and four CornFit® dosage groups. Body weight, food intake, fat mass and metabolic parameters were assessed throughout the study. Biochemical markers, gene expression in liver tissue and histopathological analysis were also performed. Results: Supplementation with CornFit® notably decreased body weight gain, fat mass and enhanced lipid profile compared to the HFD group. It also decreased pro-inflammatory markers and insulin levels while increasing adiponectin and leptin, indicating anti-inflammatory and metabolic benefits. RT-PCR analysis revealed downregulation of lipogenic genes and upregulation of genes involved in fatty acid metabolism and energy expenditure. Liver function tests and organ weights improved in treated groups. Conclusion: CornFit® demonstrates promising anti-obesity potential by reducing fat accumulation, improving metabolic health and modulating related gene expression.

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Published

2024-07-31

How to Cite

Shivaprasad, H. N., Soni, G., Krishnamani, M., Sravani, T., Garaga, M., & Manohar, D. (2024). Exploring the Anti-obesity Properties of Corn Silk Extract (CornFit®) in C57BL/6 Mice Induced with Obesity via a High-Fat Diet. Journal of Natural Remedies, 24(7), 1561–1569. https://doi.org/10.18311/jnr/2024/36556

Issue

Volume 24, Issue 7, July 2024

Section

Research Articles

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Copyright (c) 2024 H. N. Shivaprasad, Gaurav Soni, Madhu Krishnamani, T Sravani, Machiraju Garaga, D. Manohar (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2024-02-13
Accepted 2024-06-26
Published 2024-07-31

 

References

Kleinert S, Horton R. Rethinking and reframing obesity. The Lancet. 2015; 385(9985):2326-8. https://doi.org/10.1016/S0140-6736(15)60163-5PMid:25703115. DOI: https://doi.org/10.1016/S0140-6736(15)60163-5

Chatterjee A, Gerdes MW, Martinez SG. Identification of risk factors associated with obesity and overweight - a machine learning overview. Sensors (Switzerland). 2020; 20(9). https://doi.org/10.3390/s20092734 PMid:32403349 PMCid: PMC7248873. DOI: https://doi.org/10.3390/s20092734

Safaei M, Sundararajan EA, Driss M, Boulila W, Shapi’i A. A systematic literature review on obesity: Understanding the causes and consequences of obesity and reviewing various machine learning approaches used to predict obesity. Comput Biol Med. 2021; 136:104754. https://doi.org/10.1016/j.compbiomed.2021.104754 PMid:34426171. DOI: https://doi.org/10.1016/j.compbiomed.2021.104754

Okunogbe A, Nugent R, Spencer G, Ralston J, Wilding J. Economic impacts of overweight and obesity: Current and future estimates for eight countries. BMJ Glob Heal. 2021; 6(10). https://doi.org/10.1136/bmjgh-2021-006351 PMid:34737167 PMCid: PMC8487190. DOI: https://doi.org/10.1136/bmjgh-2021-006351

Guo J, Liu T, Han L, Liu Y. The effects of corn silk on glycaemic metabolism. Nutr Metab. 2009; 6:1-6. https://doi.org/10.1186/1743-7075-6-47 PMid:19930631 PMCid: PMC2785813. DOI: https://doi.org/10.1186/1743-7075-6-47

Cha JH, Kim SR, Kang HJ, Kim MH, Ha AW, Kim WK. Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets. Nutr Res Pract. 2016; 10(5):501-6. https://doi.org/10.4162/nrp.2016.10.5.501 PMid:27698957 PMCid: PMC5037067. DOI: https://doi.org/10.4162/nrp.2016.10.5.501

Shao S, Hernandez J, Svanberg U, Jia X. Bioactive compounds in corn silk (Maydis stigma): A review. Food Sci Nutr. 2018; 6(6):1347-53.

Ganesan K, Xu B. A critical review on phytochemical profile and health-promoting effects of maysin found in corn silk. Food Sci Hum Well. 2018; 7(1):11-9. https://doi.org/10.1016/j.fshw.2017.11.002 DOI: https://doi.org/10.1016/j.fshw.2017.11.002

Kim SH, Park JG, Lee J, Joo SH, Kim YS, Jeong HS. The preventive effect of corn silk on obesity in vitro and in vivo. J Funct Foods. 2014; 10:295-304.

Lee HS, Choi YJ, Cho GO, Choi HS. Corn silk (Stigma maydis) inhibits adipogenesis by the regulation of adipogenesis-related genes in 3T3-L1 adipocytes. J Med Food. 2007; 10(4):720-726.

Choi HS, Cho GO, Rahman MA, et al. Anti-obesity effect of corn silk extract in high-fat diet-induced obese mice. J Med Food. 2015; 18(3):346-52.

Tian J, Chen JW, Gao JS, Li L, Xie XH. Corn silk extracts rich in maysin possessed anti-inflammatory properties and prevented the secondary spread of bacteria from initial acute pneumonia. J Funct Foods. 2019; 52:479-87.

Lee HS, Kim YJ, Lee SH, Lee BY, Kim SH, Choi HS. Antiobesity effect of 3-deoxyanthocyanins-rich extract from purple corn and association with hormone-sensitive lipase. J Med Food. 2015; 18(3):346-52.

Xu R, Yuan G, Du Y, et al. Extraction optimisation, characterisation, and antioxidant activity of polysaccharides from corn silk. Int J Biol Macromol. 2018; 111:134-41. https://doi.org/10.1016/j.ijbiomac.2018.01.088 PMid:29355635. DOI: https://doi.org/10.1016/j.ijbiomac.2018.01.088

Tian J, Chen JW, Gao JS, Li L, Xie XH. Corn silk extracts rich in maysin possessed anti-inflammatory properties and prevented the secondary spread of bacteria from initial acute pneumonia. J Funct Food. 2019; 52:479-87.

Liu Y, Zhang L, Song H, Ji G, Mei X. Purification, characterisation, antioxidant activity and anti-inflammatory activity of polysaccharides from corn silk. Carbohydrate Polymers. 2015; 130:126-32.

Kim JH, Shin HS, Kim JW, Park HJ. Policosanol, folic acid and ginseng extract improve physical performance via anti-fatigue activity in high-fat diet-induced obese mice. J Med Food. 2017; 20(5):441-8.

Yimam M, Jiao P, Hong M, Brownell L, Lee YC, Hyun EJ. Evaluating the anti-inflammatory potential of CORNSILK. Journal of Medicinal Food. 2017; 20(8):784-791.

Suttiarporn P, Komindr S, Siriwan D, et al. Corn silk supplementation improves glycemic control and lipid profile in patients with type 2 diabetes mellitus: A randomised double-blinded placebo-controlled clinical trial. J Complement Integer Med. 2021; 18(2).

Lee Y, Jin JH, Park SK. Corn silk (Zea mays L.) in healthcare: A comprehensive review of potential health benefits. Trends Food Sci Technol. 2021; 114:186-198.

Chen J, Li L, An Y, Chen Y. The effects of corn silk on glycaemic metabolism. Nutrition and Diabetes. 2018; 8(1):1-8. https://doi.org/10.1038/s41387-017-0009-6 PMid:29330446 PMCid: PMC5851431. DOI: https://doi.org/10.1038/s41387-017-0009-6

Lee MR, Kim JE, Choi JY, Park JJ, Kim HR, Song BR, Choi YW, Kim KM, Song H, Hwang DY. Anti-obesity effect in high-fat diet-induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris. Exp Ther Med. 2019; 17(3):2185-93. https://doi.org/10.3892/etm.2019.7191 DOI: https://doi.org/10.3892/etm.2019.7191