Anti-Diarrhoeal Activity of <I>Abutilon indicum</I> Linn Leaf Extract

V. M. Chandrashekhar; A. N. Nagappa; T. S. Channesh; P. V. Habbu; K. P. Rao

doi:10.18311/jnr/2004/375

Jump To References Section

Authors

V. M. Chandrashekhar
,IN
A. N. Nagappa
,IN
T. S. Channesh
,IN
P. V. Habbu
,IN
K. P. Rao
,IN

DOI:

https://doi.org/10.18311/jnr/2004/375

Keywords:

Abutilon indicum, Loperamide, Antidiarrhoeal Activity, Albino Rats.

Therapeutic Drug Monitoring

Abstract

Objective: The present study is aimed to evaluate the leaf extracts of Abutilon indicum for acclaimed anti-diarrhoeal activity using albino rats. Materials and methods: Anti-diarrhoeal activity of Abutilon indicum was evaluated by gastro intestinal motility, castor oil-induced diarrhoea and prostaglandin E₂ -induced enteropooling in rats. Loperamide was used as a standard drug. Results : The study revealed that, the methanolic extract and aqueous extract possessed significant antidiarrhoeal activity in castor oil-induced diarrhoea and prostaglandin E₂-induced diarrhoea, compared to the control group. Conclusion: Abutilon indicum showed significant anti-diarrhoeal activity as compared to loperamide and can be recommended for further studies.