Effect of Ziziphus jujuba Leaves Extract on Phagocytosis by Human Neutrophils

Abstract

Objective: To study the effect of hydroalcoholic extract of Ziziphus jujuba leaves on neutrophil phagocytic function. Methods: The different concentrations (5, 10, 25, 50 and100 μg/ml) of Ziziphus jujuba leaves extract was subjected, to study its effect on different in vitro methods of phagocytosis such as neutrophil locomotion and chemotaxis test, in vitro immunostimulant activity by slide method and qualitative nitro blue tetrazolium test using human neutrophils. Results: The Ziziphus jujuba leaves extract has stimulated chemotactic, phagocytic and intracellular killing potency of human neutrophils at the concentration range of 5-50μg/ml. Conclusion: The hydroalcoholic extract of Ziziphus jujuba leaves stimulates cell-mediated immune system by increasing neutrophil phagocytic function.