Cytotoxic Activity of Methanolic Extract and Two Alkaloids Extracted from Seeds of <I>Peganum harmala</I> L.

Hicham Berrougui; Miguel Lopez-lazaro; Carmen Martin-Cordero; Mohamed Mamouchi; Abdelkader Ettaib; Maria Dolores Herrera

doi:10.18311/jnr/2005/413

Cytotoxic Activity of Methanolic Extract and Two Alkaloids Extracted from Seeds of Peganum harmala L.

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Authors

Hicham Berrougui
,ES
Miguel Lopez-lazaro
,ES
Carmen Martin-Cordero
,ES
Mohamed Mamouchi
,MA
Abdelkader Ettaib
,MA
Maria Dolores Herrera
,ES

DOI:

https://doi.org/10.18311/jnr/2005/413

Keywords:

Peganum harmala, Harmine, Harmaline, Cytotoxicity, TK-10, MCF-7, UACC-62.

Therapeutic Drug Monitoring

Abstract

Objective: To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L. and have been characterized by spectroscopic-Mass and NMR methods. The cytotoxicity of the methanolic extract and both alkaloids has been investigated in the three human cancer cell lines UACC-62 (melanoma), TK- 10 (renal) and MCF-7 (breast) and then compared to the positive control effect of the etoposide. Results and conclusion: The methanolic extract and both alkaloids have inhibited the growth of these three cancer cell-lines and we have discussed possible mechanisms involved in their cytotoxicity.

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Published

2005-01-01

How to Cite

Berrougui, H., Lopez-lazaro, M., Martin-Cordero, C., Mamouchi, M., Ettaib, A., & Herrera, M. D. (2005). Cytotoxic Activity of Methanolic Extract and Two Alkaloids Extracted from Seeds of <I>Peganum harmala</I> L. Journal of Natural Remedies, 5(1), 41–45. https://doi.org/10.18311/jnr/2005/413