Evaluation of Antidiabetic Activity of Indigofera prostrate on Normal and Streptozotocin Induced Diabetic Albino Wistar Rats
Authors
-
Department of Pharmacology, CMR College of Pharmacy, Kandlakoya-, Medchal, Hyderabad - 501401, Telangana ,IN
Manjeera Kuchi -
Department of Pharmaceutical Chemistry, GITAM School of Pharmacy, GITAM (Deemed to be University), Gandhi Nagar, Rushikonda, Visakhapatnam - 530045, Andhra Pradesh ,INRaja Sundararajan
DOI:
https://doi.org/10.18311/jnr/2024/41993Keywords:
Control Group, Diabetes Mellitus, Hypoglycemic Action, Indigofera prostrate, Streptozotocin, Wistar RatsAbstract
Background: Diabetes mellitus is an ailment that affects majority of individuals in the world. The objective of the current study is to estimate the antidiabetic effect of methanol extract of Indigofera prostrata whole plant, which is cultivated extensively in India’s arid and also desert regions. Aim: The aim of the current investigation is to estimate the efficacy of methanol extract of I. prostrata (MEIP) to prevent streptozotocin-induced diabetes mellitus in albino wistar strain rats. Methods: In current examination, methanol extracts of the whole plant of I. prostrata with the doses of 250 and 500mg/kg/b.wt (body weight) are administered through oral route to the streptozotocin made diabetic animals where n=6. We evaluated the differences in water intake, intake of food, glucose in fasting, weight of body and also the oral glucose tolerance test. When extract of I. prostrata was used for evaluating the (OGTT) Oral Glucose Tolerance Test for diabetic animals, levels of glucose were found to be pointedly lower when administered with 500 mg/kg b.wt as associated to the control group. I. prostrata had specifically reduced the elevated levels of glucose in diabetic rats. I. prostrata is a vital alternative source for managing blood glucose levels in diabetes mellitus that have increased during the condition and need to be further reduced by oral medications that cause hypoglycemia. Biochemical parameters were estimated as a part of the investigation. Results: The results demonstrated that the dried methanol extract of I. prostrata (250 mg/kg/bwt and 500 mg/kg/bwt) considerably declined the levels of blood glucose during the treatment period when compared to glibenclamide (10mg/kg), enhanced the metabolism, improved the health of animals and also enhanced the oral glucose tolerance test. Conclusion: As a result, we can conclude that the whole plant of I. prostrata methanol extract contains antidiabetic activity.
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Copyright (c) 2024 Manjeera Kuchi, Raja Sundararajan (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-08-27
Published 2024-11-06
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