Exploring the Anti-Diabetic Potential of Cichorium intybus through Integrated Network Pharmacology Analysis and Molecular Docking Validation

Abstract

Background: The major global health concern known as Type 2 Diabetes Mellitus (T2DM) ischaracterized by increased blood sugar level and insulin resistance. It is a common and complicated metabolic illness that needs to be understood from many angles in order to be predicted and treated effectively. Aim: Therefore, in his study, we aim to reveal the accurate and in-depth roots to predict the progression of diabetes and its management. Methods: A workable compound-target-pathway network pharmacology model and molecular docking studies were created by combining compound screening and target prediction. This model enabled researchers to systematically anticipate potential compounds and the mechanisms of Cichorium intybus anti-diabetic actions. Results: The results of the network pharmacology study were subsequently verified by using molecular docking, which effectively identified several active compounds of C. intybus and several targets that support anti-diabetes. For analytical purposes, four primary active chemicals are considered here: myricetin, cyanidin, quercitrin, and chicoric acid. These compounds act on targets such as alpha-amylase (1B2Y) and alpha-glucosidase (3W37). Here network pharmacology is used to build an interactive, complete network of genes relevant to diabetes, proteins, and pathways then validation is done through docking. Docking score of all 5 active compounds for both the targets alpha-glucosidase (PDB:3W37) and alpha-amylase (PDB:1B2Y) are considered. So, compound quercetin and cyanidin with both targets show the strongest binding affinities and interactions. Conclusion: Thus, this research successfully concludes the prediction of the active chemicals and targets of C. intybus for the treatment of diabetes. It offers fresh perspectives on the pharmacological and molecular foundations of C. intybus.