Hypoglycemic and Hypolipidemic Activities of Terminalia arjuna Stem Bark in Alloxan Induced Diabetic Rats

Abstract

Objective: To study the effect of 50% ethanolic extract of Terminalia arjuna bark on glucose and lipid profile in serum, kidney, liver and adipose tissue in alloxan induced diabetic rats. Methods: Oral administration of the Terminalia arjuna stem bark extract daily at a dose of 250 and 500 mg/kg body weight to alloxan induced diabetic rats for a period of 30 days. Results: Significant reduction in glucose and lipid profile in serum and tissues of alloxan induced diabetic rats was noticed, the extract even under high concentration (500 mg/kg body weight) showed no toxic effect in control rats. Conclusion: The study indicates that Terminalia arjuna 50 % ethanolic stem bark extract at both doses, 250 and 500 mg/ kg body weight, restored all the lipids and glucose parameters to near normal values and the dose of 500 mg/kg body weight showed more effect.