Lipotropic Activity of Natchol, a Polyherbal Formulation in Albino Wistar Rats

Abstract

The present study evaluates the lipotropic activity of Natchol, a polyherbal formulation, on carbon tetrachloride (CCl₄) induced fatty liver in male albino Wistar rats. Fatty liver was induced by intraperitoneal injection of CCl₄ at 0.1 ml/kg b.w. on 7^th and 8th day of treatment. Natchol was administered orally at 100 mg/kg b.w. while choline chloride was given at the dose of 200 mg/kg b.w. for seven days prior to CCl₄ treatment. The administration of Natchol and choline chloride was continued till 72 hours after the second dose of CCl₄. Natchol treatment significantly reduced (p≤0.05) the hepatic triglycerides level and ameliorated the reduction in weight gain induced by CCl₄. The histopathological examination of liver further corroborated the lipotropic activity of Natchol and it was found to be comparable with that of choline chloride, the positive control. Thus the present study revealed the lipotropic effect of Natchol in hepatic steatosis.