Alpha-Glucosidase Inhibitory and Hypoglycemic Activities of Piper trioicum Extract

Abstract

Alpha glucosidase in vitro inhibitory activity and hypoglycemic effect by oral administration in rats of Piper trioicum ethanol extracts have been investigated. Piper trioicum extract showed in vitro inhibitory activity of intestinal alpha glucosiadse enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was maximum at 500 mcg/ml of Piper trioicum. The purpose of study was to know whether Piper trioicum extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. The post prandial elevation in blood glucose level at 60 and 120 min after administration of maltose with Piper trioicum extracts (200 mg/kg and 400 mg/kg doses) showed significant suppression compared to control group. These results suggest that the Piper trioicum extract has potent alpha glucosidase inhibitory activity and would be effective in suppression of elevation in blood glucose after oral administration of maltose to rats.