Tea Polyphenols as Natural Products for Potential Future Management of HIV Infection - an overview

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Authors

  • Hamid Reza Sodagari
     Young Researchers & Elite Club, Karaj Branch, Islamic Azad University, Karaj ,IR
  • Roodabeh Bahramsoltani
     Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran ,IR
  • Mohammad Hosein Farzaei
     Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah ,IR
  • Amir Hossein Abdolghaffari
     Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj ,IR
  • Nima Rezaei
     Research Center for Immunodeficiency, Children's Medical Center, Tehran University of Medical Sciences, Tehran ,IR
  • Andrew W. Taylor-Robinson
     School of Medical & Applied Sciences, Central Queensland University, Rockhampton ,AU

DOI:

https://doi.org/10.18311/jnr/2016/4782

Keywords:

AIDS, Catechin, HIV, Polyphenol, Phytomedicine, Tea, Theaflavin
Therapeutic Drug Monitoring

Abstract

Belonging to the Lentivirus genus of animal retroviruses, human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency syndrome (AIDS) which attacks cells of the immune system including CD4+ T lymphocytes, monocytes, macrophages and dendritic cells. A rapid progression to immunodeficiency and the higher transmissibility of HIV-1 compared to HIV-2 are hallmarks of the worldwide spread of AIDS. Conventional HIV treatments are limited by drug toxicity and by multi-drug resistance, caused by the high genetic variability of HIV. This has led researchers into new areas of drug discovery in search of novel therapeutic molecules. Accumulating evidence indicates that tea polyphenols possess a range of beneficial properties including anti-cancer, anti-inflammatory, anti-oxidative, neuro-protective, anti-bacterial, anti-fungal and anti-viral effects. The anti-HIV infection potential of tea polyphenols has been confirmed by several preclinical studies. This suggests that polyphenol-rich extracts of tea could be used as dietary supplements as part of a combined therapeutic regimen with conventional anti-HIV drugs. Phenolic structures may also be considered as backbones for the discovery of a new generation of anti-HIV remedies. This review provides a perspective on the anti-HIV activity of tea polyphenols and their development as a possible source of future drugs for the therapy of HIV/AIDS.

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Published

2016-08-18

How to Cite

Sodagari, H. R., Bahramsoltani, R., Farzaei, M. H., Abdolghaffari, A. H., Rezaei, N., & Taylor-Robinson, A. W. (2016). Tea Polyphenols as Natural Products for Potential Future Management of HIV Infection - an overview. Journal of Natural Remedies, 16(2), 60–72. https://doi.org/10.18311/jnr/2016/4782

Issue

Volume 16, Issue 2, April 2016

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2016-05-13
Accepted 2016-07-01
Published 2016-08-18

 

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