Comparative Effect of NR-AG-I and NR-AG-II (Polyherbal formulations) against Gentamicin - Induced Nephrotoxicity in Rats

Abstract

Objective: To study the comparative effect of NR-AG-I and NR-AG-II (polyherbal formulations) against gentamicin- induced nephrotoxicity in rats. Materials and methods: Nephroprotective activity was evaluated in gentamicin induced nephrotoxicity (80mg/kg/day s.c) in male albino rats. NR-AG-I and NR-AG-II were tested at a dose of 150mg/kg/day p.o. All the treatments were given for 12 days. Urea clearance and microscopical examinations of kidney performed after the treatment. Results: Gentamicin treatment caused nephrotoxicity as evidenced by significant decrease in urea clearance and was prevented by both formulations. Study of renal microscopy showed necrosis, epithelial loss with granular degeneration and fatty changes in gentamicin treated rats and was reversed by both formulations, but NR-AG-I proven to be better formulation in our experimental study. Conclusion: Our data suggest that treatment with NR-AG-1 and NR-AG-II may be useful in reducing gentamicin nephrotoxicity in rats.