Invitro Anti-Mutagenic Potential of <i>Potentilla fulgens</i>: a Western Himalayan Plant

Prakriti Monga; Rajbir Kaur; Vikas Jaitak

doi:10.18311/jnr/2014/76

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Authors

Prakriti Monga
,IN
Rajbir Kaur
,IN
Vikas Jaitak
,IN

DOI:

https://doi.org/10.18311/jnr/2014/76

Keywords:

Co-Incubation, Inhibition, Mutation, Potentilla fulgens, Pre-Incubation.

Therapeutic Drug Monitoring

Abstract

Invitro anti-mutagenic potential of different extracts/fractions of Potentilla fulgens has been made by an Ames histidine reversion assay using TA98 and TA100 tester strains of Salmonella typhimurium against the direct-acting mutagens, 4-Nitro-O-phenylenediamine (NPD) and Sodium azide. P. fulgens has been used in traditional system of medicine as anti-hyperglycemic, hypoglycemic, anti-hyperlipidemic, anti-oxidant, anti-inflammatory and anti-ulcerogenic agent. Results indicated that n-butanol and water fractions showed strong inhibition activity against the mutagens (NPD, Sodium azide) in both co-incubation as well as pre-incubation treatments in TA98 and TA100 tester strains.