Evaluation of the Pattern and Mechanism of Bony Invasion in Gingivobuccal Sulcus and Gingival Squamous Cell Carcinoma and its Correlation with the Regional Lymph Node Metastasis: A Histopathological Study

Jump To References Section

Authors

  • Irengbam Vidyalakshmi
     Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka ,IN
  • Abhilash Pasare
     Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka ,IN
  • T. V. Narayan
     Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka ,IN
  • Chaitanya N. Babu
     Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka ,IN
  • Shobith Shetty
     Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka ,IN
  • B. V. Prakruthi
     Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka ,IN

Keywords:

Gingivobuccal complex, Erosive pattern, Invasive pattern
Oral and Maxillofacial Pathology

Abstract

Objective: The purpose of this study was to assess the frequency of bony invasion and to evaluate the pattern and mechanism of tumor invasion into the bone and its correlation with the regional lymph node metastasis in gingivobuccal sulcus (GBS) and gingival squamous cell carcinoma.
Study design: A prospective study in which 25 resected specimens of the jaws along with the associated lymph nodes of patients treated for GBS and gingival squamous cell carcinomas were evaluated for the frequency, pattern and mechanism of tumor invasion into the bone and the regional lymph node metastasis, using a light microscope.
Results: 8 of the 25 cases showed bony invasion, among which 5 (20%) showed invasive pattern of tumor invasion while 3 (12%) showed the erosive pattern into the bone. The main mechanism of bony invasion was via the cortical plate (20%) than the periodontal ligament (12%). Regional lymph node metastasis was seen in 6 of the 8 cases showing bony invasion. No significant correlation was found between any of the above parameters.
Conclusion: In our attempt to study the tumor invasion into the bone, we found no significant correlation between the pattern and mechanism of invasion and the regional lymph node metastasis. A possible treatment guide through our study to the surgeon from our side is to prevent aggressive resections and to preserve the integrity of the jaw and thus, to provide the maximum probability of cure and maintain the quality of life.

Downloads

Published

2018-09-18

How to Cite

Vidyalakshmi, I., Pasare, A., Narayan, T. V., Babu, C. N., Shetty, S., & Prakruthi, B. V. (2018). Evaluation of the Pattern and Mechanism of Bony Invasion in Gingivobuccal Sulcus and Gingival Squamous Cell Carcinoma and its Correlation with the Regional Lymph Node Metastasis: A Histopathological Study. Journal of Pierre Fauchard Academy (India Section), 31(2-4), 93–98. Retrieved from https://informaticsjournals.co.in/index.php/jpfa/article/view/21124

Issue

Volume 31, Issue 2-4, June - December 2017

Section

Original Articles

License

All the articles published in JPFA are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

 

References

Shah JS, Johnson NW, Batsakis JG. Oral Cancer. 1st ed. United Kingdom: Martin Dunitz; 2003.

Hadler-Oslen E, Wetting HL, Rikardsen O, et al. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Arch. 2010;457:677–692.

Rousseau A, Badoual C. Head and neck: squamous cell carcinoma: an overview. Atlas Genet Cytogenet Oncol Haematol. 2012;16:145–155.

Walvekar RR, Chaukar DA, Deshpande MS, et al. Squamous cell carcinoma of the gingivobuccal complex: predictors of locoregional failure in stage III–IV cancers. Oral Oncol. 2009;45:135–140.

Pathak KA, Mathur N, Talole S, et al. Squamous cell carcinoma of the superior gingival-buccal complex. Oral Oncol. 2007;43:774–779.

Ramalingam B, Ebenezer V. Retrospective analysis of survival of patients with squamous cell carcinoma of the maxilla after primary resection and elective bilateral neck dissection: an institutional experience. Ann Maxillofac Surg. 2011;1:42–47.

Fitzpatrick SG, Neuman AN, Cohen DM, Bhattacharyya I. The clinical and histologic presentation of gingival squamous cell carcinoma: a study of 519 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:509–515.

Hong SX, Cha IH, Lee EW, Kim J. Mandibular invasion of lower gingival carcinoma in the molar region: its clinical implications on the surgical management. Int J Oral Maxillofac Surg. 2001;30:130–138.

Brown JS, Browne RM. Factors influencing the patterns of invasion of the mandible by oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 1995;24:417–426.

Lubek J, El-Hakim M, Salama AR, Liu X, Ord RA. Gingival carcinoma: retrospective analysis of 72 patients and indications for elective neck dissection. Br J Oral Maxfac Surg. 2011;49:182–185.

Ogura I, Kurabayashi T, Amagasa T, Okada N, Sasaki T. Mandibular bone invasion by gingival carcinoma on dental images as an indicator of cervical lymph node metastasis. Dentomaxillofac Radiol. 2002;31:339–343.

Pandey M, Rao LP, Das SR, Mathews A, Chacko EM, Naik BR. Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region. World J Surg Oncol. 2007;5:12–17.

Woolgar JA. Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2006;42:229–239.

Nomura T, Shibahara T, Cui NH, Noma H. Patterns of mandibular invasion by gingival squamous cell carcinoma. J Oral Maxillofac Surg. 2005;63:1489–1493.