Clinical Evaluation of Thermoresponsive and Mucoadhesive Chitosan In Situ Gel Containing Levofloxacin and Metronidazole in The Treatment of Periodontal Pockets – A Split-mouth, Clinical Study

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Authors

  • Monika Bansal
     Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005 ,IN
  • Neelam Mittal
     Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005 ,IN
  • Sarita K. R. Yadav
     Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005 ,IN
  • Gyasuddin Khan
     Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005 ,IN
  • Brahmeshwar Mishra
     Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005 ,IN
  • Gopal Nath
     Department of Microbiology, Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005 ,IN

Keywords:

Chitosan, In Situ Gel, Mucoadhesive, Periodontal Pocket, Thermoresponsive
Pharmaceutics

Abstract

Objectives: Recently, mucoadhesive formulations have become popular as drug delivery for periodontal pocket and oral mucosa. The objective of this study was to evaluate the clinical efficacy of thermoresponsive and mucoadhesive chitosan in situ gel in treatment of chronic periodontitis.
Methods: Vehicle and medicated in situ gel containing Levofloxacin and Metronidazole was applied in ten systemically healthy subjects (20–50 yrs) with chronic periodontitis adjunctive to scaling and root planing (SRP) in comparison to SRP alone. Clinical parameters were plaque index (PI), gingival index (GI), and bleeding on probing (BoP), which were recorded at baseline and 15th, 30th, 60th, and 90th days, as well as probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (GR), which were recorded at baseline and 30th, 60th, and 90th days.
Results: The results suggested that changes in clinical parameters were significant from baseline for all groups on the 90th day. On the 90th day, PI was 0.7 ± 0.48, 0.4 ± 0.51, and 0.3 ± 0.48; GI was 0.6 ± 0.051, 0.5 ± 0.52, and 0.3 ± 0.48; BoP was 0.5 ± 0.52, 0.3 ± 0.48, and 0.2 ± 0.42; PPD reduction was 2.5 ± 0.52 mm, 3.4 ± 0.69 mm, and 4.6 ± 0.51 mm; CAL gain was 1.2 ± 0.42 mm, 2.6 ± 0.84 mm, and 3.8 ± 0.42 mm; and GR was 1.1 ± 0.73 mm, 1.0 ± 0.00 mm, and 0.5 ± 0.52 mm for SRP, vehicle, and medicated in situ gel groups, respectively. Reduction in PPD and gain in CAL was also significant after comparison between the treatment groups.
Conclusion: Vehicle and medicated in situ gel showed better clinical outcomes as compared to SRP alone, which could be attributed to the presence of chitosan that is not only effective in treatment of periodontitis but also acts as a good carrier to deliver drug into periodontal pockets.

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Published

2018-09-07

How to Cite

Bansal, M., Mittal, N., Yadav, S. K. R., Khan, G., Mishra, B., & Nath, G. (2018). Clinical Evaluation of Thermoresponsive and Mucoadhesive Chitosan In Situ Gel Containing Levofloxacin and Metronidazole in The Treatment of Periodontal Pockets – A Split-mouth, Clinical Study. Journal of Pierre Fauchard Academy (India Section), 30(1), 6–14. Retrieved from https://informaticsjournals.co.in/index.php/jpfa/article/view/22189

Issue

Volume 30, Issue 1, March 2016

Section

Original Articles

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All the articles published in JPFA are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

 

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