Correlation Between Nitric Oxide Concentration (No2 + No3) In Saliva And CD4+ Count In HIV Infected Adult Individuals of Mangalore, Karnataka, India

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Authors

  • Mithra N. Hegde
     Department of Conservative Dentistry and Endodontics, A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka ,IN
  • Shilpa S. Shetty
     Nitte Education Centre for Science Education and Research, K.S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka ,IN
  • Amit Malhotra
     Department of Conservative Dentistry and Endodontics, A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka ,IN
  • Nidarsh D. Hegde
     Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka ,IN

Keywords:

Nitric Oxide, Saliva, Dental Caries, HIV
Oral and Maxillofacial Surgery

Abstract

Aims: To investigate the correlation between nitric oxide concentration (NO2 + NO3) in saliva and CD4+ count in HIV infected individuals. Study design: A cross-sectional study was carried out among 60 proven HIV-positive patients selected randomly from the ART centres.

Methodology: Two groups e Control (n = 30) and study group (n = 60). The study group was divided into Group I (CD4+ count >200/cu.mm) and Group II (CD4+ count<200/cu.mm). Unstimulated saliva was collected and nitric oxide (NO2 + NO3) was estimated by Griess method. Statistical analysis was performed using One-way ANOVA and Tukey's Multiple Comparison Test.

Results: The mean level of nitric oxide (NO2 + NO3) in control group was 43.95 ± 3.64 and in Group I with CD4 >200/cu.mm and Group II with CD4 <200/cu.mm was 51.98 ± 4.08 and 59.78 ± 4.18 respectively. ‘p' value was statistically significant (P < 0.0001). The mean difference between Control and Group I was -7.937 (P < 0.001), Control and Group II was -15.80 (P < 0.001) and Group I and Group II was -7.867 (P < 0.001) from Tukey's Multiple Comparison Test.

Conclusions: From our study it is now evident that salivary nitric oxide (NO2 + NO3) can serve as an indicator of HIV replication and saliva shows a strong potential to perform tests that are done currently in blood.

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Published

2018-09-12

How to Cite

Hegde, M. N., Shetty, S. S., Malhotra, A., & Hegde, N. D. (2018). Correlation Between Nitric Oxide Concentration (No<sub>2</sub> + No<sub>3</sub>) In Saliva And CD4+ Count In HIV Infected Adult Individuals of Mangalore, Karnataka, India. Journal of Pierre Fauchard Academy (India Section), 28(2), 43–46. Retrieved from https://informaticsjournals.co.in/index.php/jpfa/article/view/22229

Issue

Volume 28, issue 2, June 2014

Section

Original Articles

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All the articles published in JPFA are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

 

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