Incidence of Multidrug Resistance Gene 1 3435C/T Single Nucleotide Polymorphism in Patients with Amlodipine Induced Gingival Enlargement – A Case Control Study

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Authors

  • Sharmila Karthikeyan
     Post graduate student, Department of Periodontics, Tamilnadu Government Dental College and Hospital, Chennai ,IN
  • K. Malathi Subramanioum
     Head of the Department, Department of Periodontics, Tamilnadu Government Dental College and Hospital, Chennai ,IN
  • Arvind Ramanathan
     Researcher, Balaji Dental College and Hospital, Chennai ,IN

Keywords:

Digo, Genetic Predisposition, Risk Factor
Periodontics

Abstract

Background: Periodontal diseases are multifactorial in nature with genetic cause as one of the risk factors. In current era, periodontal researches have widely expanded to explore the genetic background of periodontal diseases. Also, genetic predisposition remains as one of the causes for Drug-induced Gingival enlargement.

Objective: To identify MultiDrug Resistance gene (MDR) 1 C3435T single nucleotide polymorphism (SNP) in patients under amlodipine therapy with and without gingival enlargement. Methods: About 50 hypertensive patients were selected. They were divided into two groups; in that, 25 hypertensive subjects under amlodipine therapy with drug-induced gingival enlargement and 25 hypertensive subjects under amlodipine therapy with healthy gingiva were included as study and control group respectively. The blood Samples were collected from both groups for analyzing genotype distribution and finding the association of C3435T SNP with drug-induced gingival enlargement by PCR method.

Results: Our present study demonstrated no significant difference between genotypes and severity of gingival enlargement as the p value was less than significance value of 0.05. Therefore, the study concludes there is no association of gingival enlargement with specific genotype.

Conclusion: Within the limits of the present study, it can be concluded that the susceptibility for drug-induced gingival overgrowth is not influenced by the MDR 1 C3435T single nucleotide polymorphism. Since the study was undertaken in a small sample size, definite conclusion cannot be drawn. Hence, further genetic studies in MDR 1 gene in a large population are necessary for justifying the genetic predisposition to drug-induced gingival overgrowth.

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Published

2018-09-18

How to Cite

Karthikeyan, S., Subramanioum, K. M., & Ramanathan, A. (2018). Incidence of Multidrug Resistance Gene 1 3435C/T Single Nucleotide Polymorphism in Patients with Amlodipine Induced Gingival Enlargement – A Case Control Study. Journal of Pierre Fauchard Academy (India Section), 30(3-4), 67–70. Retrieved from https://informaticsjournals.co.in/index.php/jpfa/article/view/22264

Issue

Volume 30, issue 3-4, September - December 2016

Section

Original Articles

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All the articles published in JPFA are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

 

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