Serum Lipoproteins and Chronic Periodontitis – A Diagnostic Dilemma

Jump To References Section

Authors

  • Faculty of Dental Sciences, SGT University, Gurgaon, Haryana 122001 ,IN
  • Faculty of Dental Sciences, SGT University, Gurgaon, Haryana 122001 ,IN
  • Faculty of Dental Sciences, SGT University, Gurgaon, Haryana 122001 ,IN
  • Faculty of Dental Sciences, SGT University, Gurgaon, Haryana 122001 ,IN

Keywords:

Chronic Periodontitis, High-density Lipoprotein (HDL), Low-density Lipoprotein (LDL), Cholesterol, Triglycerides
Oral and Maxillofacial Pathology

Abstract

Objective: To check whether any association can be established between chronic periodontitis and abnormal serum lipoproteins levels.

Methods: A case–control study was designed including 72 subjects (both male and female) falling in the age group of 30–60 years, reporting to the department of periodontology of Faculty of dental sciences; of which, 37 were established as cases, and 35 were identified as controls based on clinical and periodontal parameters. Clinical parameters included serum lipoproteins such as high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), cholesterol, and triglycerides, and the periodontal parameters included clinical attachment level (CAL) and probing pocket depth (PPD).

Results: A statistically significant increase in the incidence of periodontitis was noticed with increasing age (p = 0.05). However, a comparison of gender with incidence of periodontitis failed to reveal significant results (p > 0.087). Statistically significant results were not obtained (p > 0.05), when mean values for each variable viz. HDL, LDL, Cholesterol and TG were compared among cases and controls.

Conclusion: No statistically significant results could be established; as a result, more samples along with controlled confounding factors need to be judged to establish any possible link between chronic periodontitis and abnormal serum lipoprotein levels.

Published

2018-09-18

How to Cite

Grover, H. S., Saini, R., Dikshit, S., & Blaggana, A. (2018). Serum Lipoproteins and Chronic Periodontitis – A Diagnostic Dilemma. Journal of Pierre Fauchard Academy (India Section), 29(2-3), 54–58. Retrieved from https://informaticsjournals.co.in/index.php/jpfa/article/view/22269

Issue

Section

Original Articles

 

References

Stamler J. Research related to risk factors. Circulation. 1979;60:1575–1587.

Nikoskelainen J, Kalliomaki JL, Lapinleimu K, Stenvik M, Halonen PE. Coxsachie B virus antibodies in myocardial infarction. Acta Med Scand. 1983;214:24–32.

Syrjanen J, Valtonen VV, Livanainen M, Kaste M, Huttunen JK. Preceding infection as a major risk for ischaemic brain infarction in young and middle aged patients. Br Med J (Clin Res Ed). 1988;296:1156–1160.

Feingold KR, Staprans I, Memon RA, et al. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res. 1992;33:1765–1776.

Dinarello CA. Interleukin-1 and interleukin 1 antagonism. Blood. 1991;77:1627–1652.

DeStephano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. BMJ. 1993;306:688–691.

Moeintaghavi A, Haerian-Ardakani A, Talebi-Ardakani M, Tabatabaie I. Hyperlipidemia in patients with periodontitis. J Contemp Dent Pract. 2005;6:78–85.

Losche W, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol. 2000;29:537–541.

Machado AC, Quirino MR, Nascimento LF. Relation between chronic periodontal disease and plasmatic levels of triglycerides, total cholesterol and fractions. Braz Oral Res. 2005;19:284–289.

Valentaviciene G, Paipaliene P, Nedzelskiene I, Zilinskas J, Anuseviciene OV. The relationship between blood serum lipids and periodontal conditions. Stomatologica. 2006;8:96–100.

Brotto RS, Vendramini RC, Brunetti IL, Marcantonio RA, Ramos AP, Pepato MT. Lack of correlation between periodontitis and renal dysfunction in systemically healthy patients. Eur J Dent. 2011;5:8–18.

Taleghani F, Shamaei M, Shamaei M. Association between chronic periodontitis and serum lipid levels. Acta Med Iran. 2010;48:47–50.

Hernichel-Gorbach E, Kornman KS, Hole SC, et al. Host responses in patients with generalized refractory periodontitis. J Periodontol. 1994;65:8–16.

Todd JA. Genetic control autoimmunity in type I diabetes. Immunol Today. 1990;11:122–129.

Morel DW, Dicorleto PE, Chisholm GM. Modulation of endotoxin (LPS-induced) endothelial cell toxicity by low density lipoprotein (LDL). Lab Invest. 1986;55:419–426.

Hadi AR, Carr CS, Suwaidi JL. Endothelial dysfunction: cardiovascular risk factors, therapy and outcomes. Vasc Health Risk Manag. 2005;1:183–198.

Mahdy Ali K, Wonnerth A, Huber K, Wojta J. Cardiovascular disease risk reduction by raising HDL cholesterol – current therapies and future opportunities. Br J Pharmacol. 2012;167:1177–1194.

Kertula Y, Weber TH. Serum lipids in viral and bacterial meningitis. Scand J Infect Dis. 1986;18:211–215.

Li X. Systemic diseases caused by oral infection. Clin Microbiol Rev. 2000;13:547–558.

Rasi V, Ikkala E, Valtonen V. Plasma beta-thromboglobulin in severe infection. Thromb Res. 1982;26:267–274.

Ishida T, Tanaka K. Effects of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in culture. Atherosclerosis. 1982;44: 161–174.

Semerano N, Lattanzio A. Interaction of platelets and bacterial endotoxins. Agents Actions. 1983;13:461–469.

Stuart MJ. Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. Am J Hematol. 1981;11:159–164.

Tofter GH, Brezinski D, Schafer AI, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and cardiac death. N Engl J Med. 1987;316: 1514–1518.

Hujoel PP, Drangsholt M, Spiekerman C, De Roven TA. Periodontitis – systemic disease associations in presence of smoking – causal or coincidental? Periodontol 2000. 2002;30:51–60.

Nishimura F, Takahashi K, Kurihara M, Takashiba S, Murayama Y. Periodontal disease as a complication of diabetes mellitus. Ann Periodontol. 1998;3:20–29.

Liu LS, Spelleken M, Rohrig K, Haunser H, Eckel J. Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the P80 tumor necrosis factor receptor. Diabetes. 1998;47:515–522.

Ylostalo PV, Ek E, Laitinen J, Knuultila ML. Optimism and life satisfaction as determinant for dental and general health behavior-oral health habits linked to cardiovascular risk factors. J Dent Res. 2003;82:194–199.

Katz J, Chaushu G, Sharabi Y. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol. 2001;28:865–868.

Vilkuna-Rautianen T, Pussinen PJ, Roivainen M, et al. Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease. Int J Epidemiol. 2006;35:1486–1494.