Drug Resistance Patterns among XDR-TB Patients visiting a TB Centre at a Tertiary Health Care Facility

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Authors

  • Gauri Suhas Kulkarni
     Professor, Department of Respiratory Medicine, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra ,IN
  • Abhijit Janardhan Telkhade
     Former PG Resident, Department of Respiratory Medicine, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra ,IN
  • Sushama Dugad
     Associate Professor, Department of Respiratory Medicine, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra ,IN

DOI:

https://doi.org/10.18311/mvpjms/2020/v7i1/22963

Keywords:

Diabetes, Drug Sensitivity, Fluoroquinolones, XDR TB, MDR TB

Abstract

Background: Resistance to MDR TB has additional resistance to fluoroquinolones and second line injectables it is defined as XDR-TB. The present study is designed to evaluate drug resistance patterns in such XDR patients. Aims and Objectives: To study drug resistance patterns in XDR-TB patients. Material and Methods: Researcher carried out a cross-sectional study over a period of two years. In this study, 43 patients were studied. The criteria used to observe was that – Newly diagnosed cases of XDR-TB patients by using the second line Drug Sensitivity Testing (DST). This method was used at an accredited RNTCP lab regardless of age and gender of the patients. Further, demographic, clinical and treatment data were analyzed in terms of drug sensitivity of the patients. Results: 48.83% of patients showed resistance with fluoroquinolone, 20.93% showed resistance with XDR with Second line injectables, 30.23% with flouroquinolones + second line injectibles. Maximum resistance was seen in Ofloxacin (81.4%) followed by kanamycin (44.2%). 41.86% patients were diabetics showing that drug resistance was more prevalent in these population. Maximum defaulters (80%) were from the lower class. Conclusion: Flouroquinolones and second-line drugs must be administered rationally and considerately to prevent the widespread drug resistance. The role played by diabetes and lower socio economic status in the emergence of drug resistance must not be undermined.

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Published

2021-03-10

Issue

Volume 7, Issue 1, January - June 2020

Section

Original Research Article

 

References

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