Role of Interleukin-I Super Family in Progression of Osteoarthritis

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Authors

  • Amit Kumar
     Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007 ,IN
  • Md Arshad
     Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007 ,IN
  • Ajai Singh
     Department of Orthopaedics, King George Medical University, Lucknow – 226003 ,IN
  • Asif Jafri
     Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007 ,IN
  • Sabir Ali
     Department of Orthopedics, King George Medical University, Lucknow – 226003 ,IN
  • Manish Yadav
     Department of Orthopedics, King George Medical University, Lucknow – 226003 ,IN
  • Suchit Swaroop
     Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007 ,IN

DOI:

https://doi.org/10.18311/jeoh/2017/15979

Keywords:

Cytokine, IL-1 Family, Mode of Action, Osteoarthritis.

Abstract

Osteoarthritis (OA) is considered as multifactorial disorder characterized by erosion of articular cartilage, tightening of joint space, subchondral bone remodelling and internal synovial inflammation. OA reduces joint function progressively as a person gets older. The most important group of the cytokines or chemokines are pre-dominantly involving in the early progression of the disease includes IL-1, IL-6, IL-18 and TNF-a, etc. IL-1 family of cytokines are known to be strongest stimulus for progressive synthesis of Matrix Metallo Proteinases (MMPs). Large number of immune cells, chondrocytes and endothelial cells potentially secrete IL-1 with diverse effect on number of diseases. This review highlights the association of IL-1 family cytokine in OA.

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Published

2017-06-12

How to Cite

Kumar, A., Arshad, M., Singh, A., Jafri, A., Ali, S., Yadav, M., & Swaroop, S. (2017). Role of Interleukin-I Super Family in Progression of Osteoarthritis. Journal of Ecophysiology and Occupational Health, 17(1-2), 9–16. https://doi.org/10.18311/jeoh/2017/15979

Issue

Volume 17, Issue 1-2, June 2017

Section

Articles
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