Ovarian toxicity of benzene in rat
Authors
-
,IN
Anju Singh -
,INS.V.S. Rana
DOI:
https://doi.org/10.18311/jeoh/2010/18251Keywords:
Benzene, Ovary, Lipid peroxidation. Progesterone, CYP^^g2E1.Abstract
Present report describes ovarian toxicity of benzene in rat. Effects of benzene in ovary of rat have been attributed to increased lipid peroxidation, alterations in progesterone values and activity of CYP^^^EI. Histopathological observations confirm ovarian toxicity of benzene. Number ofprimodial follicles decreased after benzene treatment. Cortex, medulla and corpus luteum also exhibited pathological changes. It is concluded that female reproductive system is vulnerable to benzene. Since a number of female workers are exposed to organic solvents like benzene through their work environment, present obsen/ations are important from occupational health point of view
Downloads
Metrics
References
Allen, T, Singhal, R. and Rana, S.V.S. (2004) Resistance to oxidative stress in a freshwater fish Channa punctatus after exposure to inorganic arsenic. Biol. Trace Element Res., 98, 63-72.
Anders, M.W. (1988) Bioactivation mechanisms and hepatocellular damage. In: Arias IM, Jal
Arinc, E., Adali, A., Iscan, IVI. and Guray, T. (1991) Stimulatory effects of benzene on rabbit liver and l
Barber, H.R.K. (1981) The effect of cancer and its therapy upon fertility'. Int. J. Fertii., 26, 250-259.
Bulger, W.H. and Kupfer, D. (1983) Estrogenic action of DDT analogs. Am. J. Ind. Med., 4, 163 -173.
Desoille, H., Philbert, M. and Albahary, C. (1962) Effects of hormones on chronic benzene poisoning in rabbits. II. Influence of sex, castration, homologous or heterologous sex hormone therapy on leukocytosis in rabbits exposed to short-term (6 weeks) benzene poisoning. Arcli. Mai. Path., 23, 209-218.
Ellman, G.L. (1959) Tissue sulfhydryl groups. Arch. Biochem., 82, 70-77.
Foster, W.G. (2003) Environmental toxicants and human fertility, Minerva. Ginecol., 55, 451-457.
Goldstein, B.D. (1988) Benzene toxicity. Occup. Med. Rev., 3, 541-554.
Gray, K., Bullock, B., Dickson, R., Raszmann, K., Walmer, D., McLachlan, J. and Merlino, G. (1996) Potentiation of diethylstilbestrol-induced alterations in the female mouse reproductive tract by transforming growth factor-alpha transgene expression. Mol. Carcinog., 17, 163-173.
Helden, P.K., Cawen, M.J. and Hutz, R.J. (2006) Inhibition of follicular development, vitellogenesis and serum 17 betaestradiol concentrations in zebafish following chronic sublethal dietary exposure to 2,3,7,8-tetra chlorodibenzopdioxin. Toxicol. Sci., 90, 490-499.
lARC (1987) lARC monographs on the evaluation of carcinogenic risks to humans. Overall evaluations of carcinogenicity: An updating of lARC Monographs Volumes 1 to 42. SuppI 7. Lyons, France: World Health Organization, International Agency for Research on Cancer, 38-74.
Jordan, R.A. and Schenkman, J.B. (1982) Relationship between malondialdehyde production and arachidonate consumption during NADPH-supported microsomal lipid peroxidation. Biochem. Pharmacol., 31, 1393-1400.
Kato, R. and Kamataki, T. (1982) Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat. Xenobioiica, 12, 787-800.
Koop, D.R. (1986) Hydroxylation of p-nitrophenol by rabbit ethanol inducible cytochrome P450 isozymes. Mol. Pharmacol., 29, 399-404.
Kumar, S. (2004) Occupational exposure associated with reproductive dysfunction. J. Occup. HIth., 46, 1-19.
Lovekamp-Swan, T. and Davis, B.J. (2003) Mechanisms of phthalate ester toxicity in the female reproductive system. Environ. HIth. Perspect., I l l , 139-145.
Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
Maltoni, C, Ciliberti, A., Cotti, G., Conti, B. and BelpoggI, F. (1989) Benzene an experimental multipotential carcinogen, results of the long-term bioassay performed at the Bologna Institute of Oncology. Environ. HIth. Perspect., 82, 109-124.
Martinez, E.M. and Swartz, W.J. (1991) Effects of methoxychlor on the reproductive system of the adult female mouse. 1 Gross and histologic observations. Reprod. Toxicol., 5, 139-147.
Mattison, D.R. (1983) The mechanisms of action of reproductive toxins. Am. J. Ind. Med., 4, 65-79.
Mattison, D.R., Chang, L., Thorgeirsson, S.S. and Shiromizu, K. (1981) The effects of cyclophosphamide, azathioprine, and 6-mercaptopurine on oocyte and follicle number in C57BL/6N mice. Res. Commun. Chem. Pathol. Pharmacol., 31, 155-161.
Mattison, D.R, Plowchalk, DR., Meadows, M.J., Al-Juburi, A.Z., Gardy, J. and Malek.A. (1990) Reproductive toxicity male and female reproductive systems as targets for chemical injury. Med. Clin. N. Am., 74, 391-411.
Mukhtar, H., Philpot, R.M. and Bend, JR. (1978) Epoxidemetabolizing enzyme activities and cytochrome P-450 content of rat ovaries during pregnancy. Biochem. Biophys. Res. Commun., 81, 89-98.
Orzechowski, A., Schw/arz Schwegler, U., Boak, W., Snyder, R. and Schrenk, D. (1995) Benzene metabolism in rodent hepatocytes, role of sulphate conjugation Xenobiotica, 25, 1093-1102.
Rana, S.V.S. and Verma, Y. (2005) Biochemical toxicity of benzene. J. Env. Biol., 26, 157-168.
Schlosser, PM., Bond, J.A and Medinsky, MA. (1993) Benzene and phenol metabolism by mouse and rat liver microsomes. Carcinogenesis 14, 2477-2486.
Singh, A. and Rana, S.V.S. (2009) Role of oxidative stress in testicular toxicity of benzene in rat. J. Ecophysiol. Occup. HIth., 9, 11-16.
Snyder, R., Witz, G. and Goldstein, B.D. (1993) The toxicology of benzene. Environ. HIth. Perspect., 100, 293-306.
Verma, Y. and Rana, S.V.S. (2003) Gender differences in the metabolism of benzene, toluene and trichloroethylene in rat with special reference to certain biochemical parameters. J. Environ. Biol., 24, 135-140
Verma, Y. and Rana, S.V.S. (2004) Sex differences in oxidative stress induced by benzene ind rats. Ind. J. Exp. Biol., 42, 117-120.
Verma, Y. and Rana, S.V.S. (2008) Effects of progesterone on benzene toxicity in rats. Arch. Hig. Rada. Toksikol 59, 1-9.
Vidal, J.D., Vonde Vort, C.A., Maucus, C.B., Lazarewicz, N.R. and Conley. A.J. (2006) In vitro exposure to environmental tobacco smoke induces CYP1B1 expression in human luteinized granulose cells. Reprod. Toxicol., 22, 731-737.
Yamada, I., Tehihara, G., Wang, H,, Yu, X., Maeda, K., Tsukamura, H., Kamijima, M., Nakajima, T. and Takeuchi, Y (2003) Exposure to 1-bromo-propane causes ovarian dysfunction in rats. Toxicol. Sci., 71, 96-103.
