Possible occurrence of apoptosis in Endosuifan induced testicular toxicity in mice

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Authors

  • J.K. Singh
     ,IN
  • Mohammad Ali
     ,IN
  • Ranjit Kumar
     ,IN
  • A. Nath
     ,IN
  • Arun Kumar
     ,IN

DOI:

https://doi.org/10.18311/jeoh/2010/18259

Keywords:

Endosuifan, Swiss albino mice, Testis, Spermatozoa

Abstract

Endosuifan an organochlorine pesticide is known to cause deleterious effect on ttie reproductive organs of humans. In the present investigation, Endosuifan at 3.0 mg/kg b.w was administered to Swiss albino mice for 4 weeks. Animals were sacrificed and their testicular tissues were fixed for Transmission Electron microscopic study. The Electron microscopic study reveals the degenerative changes in testis at subcellular level. The plasma membrane, nuclear membrane, chromatin material and mitochondria, etc. show degenerative changes. It was concluded that Endosuifan causes damage to spermatozoa in Swiss albino mice.

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Author Biographies

J.K. Singh

Mahavir Cancer Institute and Research Centre, Phulwarisharif, Patna-801505, Bihar (India)

Mohammad Ali

Mahavir Cancer Institute and Research Centre, Phulwarisharif, Patna-801505, Bihar (India)

Ranjit Kumar

Mahavir Cancer Institute and Research Centre, Phulwarisharif, Patna-801505, Bihar (India)

A. Nath

Mahavir Cancer Institute and Research Centre, Phulwarisharif, Patna-801505, Bihar (India)

Arun Kumar

Mahavir Cancer Institute and Research Centre, Phulwarisharif, Patna-801505, Bihar (India)

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Published

2017-11-30

How to Cite

Singh, J., Ali, M., Kumar, R., Nath, A., & Kumar, A. (2017). Possible occurrence of apoptosis in Endosuifan induced testicular toxicity in mice. Journal of Ecophysiology and Occupational Health, 10(1-2), 43–47. https://doi.org/10.18311/jeoh/2010/18259

Issue

Volume 10, Issue 1-2, June 2010

Section

Articles
Crossref
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Europe PMC
Received 2017-11-28
Accepted 2017-11-28
Published 2017-11-30

 

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