Di (2-Ethylhexyl) Phthalate Induced Toxicological Effects on Reproductive System of Female Mice Mus-Musculus

Jump To References Section

Authors

  • Anjali Singh
     Department of Botany and Biotechnology, Thakur Prasad Singh (T.P.S. College) College, Patliputra University, Patna – 800020, Bihar ,IN
  • Ravish Kumar
     S. S. Hospital and Research Institute, Patna – 800020, Bihar ,IN
  • Jitendra Kumar Singh
     S. S. Hospital and Research Institute, Patna – 800020, Bihar ,IN
  • Kumar Sanbhav Singh
     S. S. Hospital and Research Institute, Patna – 800020, Bihar ,IN
  • Tanuja
     Department of Botany and Biotechnology, Thakur Prasad Singh (T.P.S. College) College, Patliputra University, Patna – 800020, Bihar ,IN

DOI:

https://doi.org/10.18311/jeoh/2019/23333

Keywords:

Corn Oil Reproductive System, DEHP, Hormones, Infertility
Toxicology

Abstract

Di-(2-ethylhexyl) phthalate is an environmental endocrine disruptor and reproductive toxicant. It impairs the structural and functional aspects of female reproduction and also alters the molecular, endocrinological, cytological and biochemical aspects, causing ovarian cycle irregularity and infertility. DEHP was orally administered at lower dose of 10 mg/kg bwt to mice for six to twenty four weeks period which resulted in alterations of the serum levels of hormones estrogen and progesterone. The altered values of hormones were found to be statistically very significant (P<0.001). The present study indicated the adverse effects of exposure of DEHP on female reproductive health.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2019-09-06

How to Cite

Singh, A., Kumar, R., Singh, J. K., Singh, K. S., & Tanuja. (2019). Di (2-Ethylhexyl) Phthalate Induced Toxicological Effects on Reproductive System of Female Mice <i>Mus-Musculus</i>. Journal of Ecophysiology and Occupational Health, 19(1-2), 71–75. https://doi.org/10.18311/jeoh/2019/23333

Issue

Volume 19, Issue 1&2, June 2019

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2019-02-16
Accepted 2019-06-11
Published 2019-09-06

 

References

Wittassek M, Weissmuller GA, Koch HM, Eckard R, Dobler L, Muller J, Angerer J, Schluter C. Internal phthalate exposure over the last two decades- aretrospective human biomonitoring study. Int J Hyg Environ Health. 2007; 210:319–33. https://doi.org/10.1016/j.ijheh.2007.01.037 PMid:17400024

JAColacino TR, Harris A, Schecter. Dietary intake is associated with phthalate body burden in a nationally representative sample, Environ. Health Perspect. 2010; 118:998–1003. https://doi.org/10.1289/ehp.0901712 PMid:20392686 PMCid:PMC2920922

Latini G, Avery GB. Materials degradation in endotracheal tubes: A potential contributor to bronchopulmonary dysplasia. Acta Pediatr. 1999; 88:1174–5. https://doi.org/10.1111/j.1651-2227.1999.tb01011.x

Latini G. The potential hazards of exposure to di-(2-ethylhexyl)phthalate in babies a review. Biol. Neonate. 2000; 78:269–76. https://doi.org/10.1159/000014278 PMid:11093005

Tickner JA, Schettler T, Guidotti T, McCally M, Rossi M. Overview of patient health risks posed by the use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices. Am J Ind Med. 2001; 39:100–11. https://doi.org/10.1002/10970274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q

US food and drug administration center for devices and radiological health. Safety assessment of di(2-ethylhexyl)phthalate (DEHP) released from PVC medical devices. Available from: http://www.fda.gov/cdrh/ost/ dehp-pvc.pdf

Health Canada Expert Advisory Panel on DEHP Final Report 2002 January 11.

Heindel JJ, Gulati DK, Mounce RC, Susan RR, Lamb JCIV. Reproductive toxicity of three phthalic acid esters in a continuous breeding protocol. Fundam Appl Toxicol. 1989; 12:508–18. https://doi.org/10.1016/0272-0590(89)90024-9

Latini G, Del Vecchio A, Massaro M, Verrotti A, De Felice C. In utero exposure to phthalates and fetal development. Curr Med Chem. 2006; 13:2527–34. https://doi.org/10.2174/092986706778201666 PMid:17017909

Latini G, Del Vecchio A, Massaro M, Verrotti A, De Felice C. In utero exposure to phthalates and fetal development. Curr Med Chem. 2006; 13:2527–34. https://doi.org/10.2174/092986706778201666 PMid:17017909

Adibi JJ, Perera FP, Jedrychowski W, Camann DE, Barr D, et al. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environ Health Perspect. 2003; 111:1719–22. https://doi.org/10.1289/ehp.6235 PMid:14594621 PMCid:PMC1241713

Latini G. Monitoring phthalate exposure in humans. Clinchim Acta. 2005; 361:20–7. https://doi.org/10.1016/j.cccn.2005.05.003 PMid:16004980

OEHHA. No, significant risk level (NSRL) for the proposition 65 carcinogen Di(2-Ethylexyl) Phthalate, California Environmental Protection Agency; 2001.

Ito Y, Yamanoshita O, Asaeda N, Tagawa Y, Lee CH Aoyama T, Ichihara G, Furuhashi K, Kamijima M, Gonzalez FJ, Nakajima T.Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway. Journal of Occupational Health. 2007; 49(3):172–82. https://doi.org/10.1539/joh.49.172 PMid:17575397

Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes longterm pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology. 2012; 153(2):937-48. https://doi.org/10.1210/en.2011-1450 PMid:22147016

Takai R, Hayashi S, Kiyokawa J, et al. Collaborative work on evaluation of ovarian toxicity. 10) Two- or four-week repeated dose studies and fertility study of di-(2-ethylhexyl) phthalate (DEHP) in female rats. J Toxicol Sci 2009; 34(Suppl 1):SP111–9. https://doi.org/10.2131/jts.34.S111 PMid:19265277

Ma M, Kondo T, Ban S. Exposure of prepubertal female rats to inhaled di(2 ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions. Toxicol Sci. 2006; 93(1):164– 71. https://doi.org/10.1093/toxsci/kfl036 PMid:16763069

Svechnikova I, Svechnikov K, Söder O. The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats. J Endocrinol. 2007; 194(3):603–9.

https://doi.org/10.1677/JOE-07-0238 PMid:17761899

Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes longterm pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology. 2012; 153(2):937–48. https:// doi.org/10.1210/en.2011-1450 PMid:22147016

Davis BJ, Maronpot RR, Heindel JJ. Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. Toxicol Appl Pharmacol. 1994; 128(2):216–23. https://doi.org/10.1006/ taap.1994.1200 PMid:7940536

Lovekamp Swan T, Davis BJ. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect. 2003; 111(2):139–45. https://doi.org/10.1289/ehp.5658 PMid:12573895 PMCid:PMC1241340

Högberg J, Hanberg A, Berglund M, et al. Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations. Environ Health Perspect. 2008; 116(3):334–9. https://doi.org/10.1289/ehp.10788 PMid:18335100 PMCid:PMC2265037

Genuis SJ. Human elimination of phthalate compounds: blood, urine, and sweat (BUS) study. Scientific World J. 2012; 2012:615068. https://doi.org/10.1100/2012/615068 PMid:23213291 PMCid:PMC3504417

Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect. 1995; 103:582–7. https://doi.org/10.1289/ehp.95103582 PMid:7556011 PMCid:PMC1519124

Harris CA, Henttu P, Parker MG, Sumpter JP. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect. 1997; 105:802–811. https://doi.org/10.1289/ehp.97105802 PMid:9347895 PMCid:PMC1470189

Maria De Falco, Maurizio Forteand Vincenza Laforgia. Estrogenic and anti androgenic endocrine disrupting chemicals and their impact on the male reproductive system. Environmental Toxicology. 2015; 3.

Bhattacharya P, Keating AF. Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity. Toxicol Appl Pharmacol. 2012; 261(3):227–35. https://doi.org/10.1016/j.taap.2012.04.009 PMid:22531813 PMCid:PMC3359424

Craig ZR, Wang W, Flaws JA. Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling. Reproduction. 2011; 142(5): 633–46.

https://doi.org/10.1530/REP-11-0136 PMid:21862696

Pocar P, Fiandanese N, Secchi C, et al. Exposure to di(2-ethylhexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology. 2012; 153(2):937–48. https://doi.org/10.1210/en.2011-1450 PMid:22147016

Zhang XF, Zhang LJ, Li L, et al. Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse. Environ Mol Mutagen. 2013; 54(5):354–61. https:// doi.org/10.1002/em.21776 PMid:23625783

Agarwal DK, Lawrence WH, Turner JE, and Autian, J. Effects of parenteral di-(2-ethylhexyl) phthalate (DEHP) on gonadal biochemistry pathology and reproductive performance of mice. J Toxicol Environ Health. 1989; 26:39–59. https://doi.org/10.1080/15287398909531232 PMid:2913333