Blood Lead Levels and their Relationship with Lead in Ambien Air in Children in the Area of used Lead-Acid Battery in Depok City, Indonesia
Authors
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National Institute of Research and Development, Ministry of Health of Republic of Indonesia, Jakarta ,ID
Basuki Rachmat -
National Institute of Research and Development, Ministry of Health of Republic of Indonesia, Jakarta ,IDDasuki
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National Institute of Research and Development, Ministry of Health of Republic of Indonesia, Jakarta ,IDHelper Sahat Parulian Manalu
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National Institute of Research and Development, Ministry of Health of Republic of Indonesia, Jakarta ,IDElsa Elsi
DOI:
https://doi.org/10.18311/jeoh/2020/26134Keywords:
Blood Lead Levels, Children, Informally Used Lead-Acid Battery, Lead in the AirAbstract
The informal Used Lead-Acid Battery (ULAB) activities impact air pollution from smoke, dust, and waste containing lead. This study aims to determine the effect of air lead concentration on Blood Lead Levels (BLLs) in children aged 7-13 years in the informally ULAB area in the city of Depok. This study uses secondary data from the 2014 Special Research on Environmental Pollution for Traditional Battery Processing conducted by the National Institute of Research and Development. Cross-sectional study design, the study population was children aged 7-13 years in selected ULAB areas, with a total sample of 94 people. Each respondent took a venous blood sample and measured it with a portable blood lead gauge. The concentration of lead in the air was measured using a High Volume Air Sampler and analyzed by atomic absorption spectrometry. Normality test on BLLs and lead variables in the air. Linear regression test to determine the relationship between lead variables in the air and BLLs. The respondents' average BLLs were 8.58 μg/dL, with intervals of 3.8 - 14.6 μg/dL. There was a strong relationship (r = 0.777) and statistically significant (p = 0.000) between air lead levels and BLLs. It has a lively pattern equation, meaning that if the lead level in the air increases, the BLLs will increase. Although BLL in children is still below World Health Organization (WHO) recommended, there needs to be measured to prevent children from being exposed to lead, because low BLLs for long periods can endanger children's health.
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Accepted 2020-10-05
Published 2020-12-29
References
Liu G, Yu Y, Hou J, Xue W, Liu X, Liu Y, et al. An ecological risk assessment of heavy metal pollution of the agricultural ecosystem near a lead-acid battery factory. Ecol. Indic. 2014. https://doi.org/10.1016/j.ecolind.2014.04.040
Zhang Y, Li S, Chen Z, Wang F, Chen J, Wang L. A systemic ecological risk assessment based on spatial distribution and source apportionment in the abandoned lead acid battery plant zone, China. J. Hazard. Mater. 2018. https://doi.org/10.1016/j.jhazmat.2018.04.054. PMid: 29751173.
ATSDR. Toxicological Profile for Lead. 2007 (August); 15675. Available from: http://www.atsdr.cdc.gov/ToxProfiles/ tp13.pdf.
Holstege CP, Dobmeier SG, Bechtel LK. Critical Care Toxicology. Emerg. Med. Clin. North Am. 2008; 26(3):715-39. https://doi.org/10.1016/j.emc.2008.04.003. PMid: 18655942.
Nussbaumer-Streit B, Yeoh B, Griebler U, Pfadenhauer LM, Busert LK, Lhachimi SK, et al. Household interventions for preventing domestic lead exposure in children. Cochrane Database of Systematic Reviews. 2016. https://doi.org/10.1002/14651858.CD006047.pub5. PMid: 27744650, PMCid: PMC6461195.
Meyer PA, Brown MJ, Falk H. Global approach to reducing lead exposure and poisoning. Mutation Research - Reviews in Mutation Research. 2008. https://doi.org/10.1016/j.mrrev.2008.03.003. PMid: 18436472.
WHO. Fact sheet: Lead poisoning and health [Internet]. 2017a. Cited on 2019 Aug 12. Available from: https://www.who.int/en/news-room/fact-sheets/detail/lead-poisoningandhealth.
Sharma P, Chambial S, Shukla KK. Lead and neurotoxicity. Indian J. Clin. Biochem. 2015; 30(1):1-2. https://doi.org/10.1007/s12291-008-0001-y, https://doi.org/10.1007/s12291-015-0480-6, https://doi.org/10.1007/BF02912872.
Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: A review. Reviews on Environmental Health. 2009. https://doi.org/10.1515/ REVEH.2009.24.1.15. PMid: 19476290, PMCid: PMC2858639.
Rachmat B, Kusnoputranto H, Inswiasri. Anemia in children due to airborne lead exposure of used lead-acid battery recycling area in Jabodetabek, Indonesia. Indian J. Public Heal. Res. Dev. 2019. https://doi.org/10.5958/09765506.2019.03823.3.
Landrigan PJ, Fuller R, Acosta NJR, Adeyi O, Arnold R, Basu N (Nil), et al. The Lancet Commission on pollution and health. Lancet. 2018; 391(10119):462-512. https://doi.org/10.1016/S0140-6736(17)32345-0.
Bellinger DC. The protean toxicities of lead: New chapters in a familiar story. International Journal of Environmental Research and Public Health. 2011. https://doi.org/10.3390/ ijerph8072593. PMid: 21845148, PMCid: PMC3155319.
Forouzanfar MH, Afshin A, Alexander LT, Biryukov S, Brauer M, Cercy K, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1659-724. https://doi.org/10.1016/S01406736(16)31679-8.
Fewtrell LJ, Prüss-íœstün A, Landrigan P, Ayuso-Mateos JL. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure. Environ. Res. 2004. https://doi.org/10.1016/ S0013-9351(03)00132-4.
Attina TM, Trasande L. Research children's health economic costs of childhood lead exposure in low- and middle-income. Environmental Health Perspective. 2013; 121(9):1097-102. https://doi.org/10.1289/ehp.1206424. PMid: 23797342, PMCid: PMC3764081.
WHO. Recycling used lead-acid batteries: Health Considerations [Internet]. 2017b. Available from: https:// www.who.int/ipcs/publications/ulab/en/.
Widjaksono AG. Recovery of Hazardous and Toxic contaminated land in Indonesia and Developing Environmentally Sound Management for Used Lead Acid Battery (ULAB) Recycling. Jakarta; 2014.
BSI. BS 1747-13: 1994 ISO 9855:1993: Measurement of air Pollution: Part 13: Determination of the Particulate Lead Content of Aerosols Collected on Filters: Atomic Absorption Spectrometric Method; 1994.
Harbert KR. Venipuncture. In: Essential Clinical Procedures. 2007. https://doi.org/10.1016/B978-1-41603001-0.50009-5.
Cornelis R, Heinzow B, Herber RFM, Christensen JM, Poulsen OM, Sabbioni E, et al. Sample collection guidelines for trace elements in blood and urine. J Trace Elem. Med. Biol. 1996. https://doi.org/10.1016/S0946672X(96)80018-6.
FDA. LeadCare II Blood Lead Analyzer. Biomed Saf Stand.2018.
WHO. Brief guide to analytical methods for measuring lead in blood. Sheffer M, editor. Geneva, Switzerland: World Health Organization; 2011.
Marmolejo-Ramos F, Siva Tian T. The shifting boxplot. A boxplot based on essential summary statistics around the mean. Int. J. Psychol. Res. 2010. https://doi.org/10.21500/20112084.823.
Olive DJ. Linear regression. Linear Regression. 2017. https://doi.org/10.1007/978-3-319-55252-1.
Hale CM, Polder JA. The ABCs of Safe and Healthy Child Care: A Handbook for Child Care Providers; 1997. p. 1-150.
Ko S, Schaefer PD, Vicario CM, Binns HJ. Relationships of video assessments of touching and mouthing behaviors during outdoor play in urban residential yards to parental perceptions of child behaviors and blood lead levels. J. Expo. Sci. Environ. Epidemiol. 2007. https://doi.org/10.1038/ sj.jes.7500519. PMid: 16941017.
Brosché S, Denney V, Weinberg J, Calonzo MC, Withanage H, Clark S. Asia Regional Paint Report. IPEN. 2014; 3:34.
Ericson B, Hariojati N, Susilorini B, Crampe LF, Fuller R, Taylor MP, et al. Assessment of the prevalence of lead-based paint exposure risk in Jakarta, Indonesia. Sci. Total Environ. 2019. https://doi.org/10.1016/j.scitotenv.2018.12.154. PMid: 30677904.
Jones RL, Homa DM, Meyer PA, Brody DJ, Caldwell KL, Pirkle JL, et al. Trends in blood lead levels and blood lead testing among US children aged 1 to 5 years, 1988 2004. Pediatrics. 2009. https://doi.org/10.1542/peds.2007-3608. PMid: 19254973.
Ferron MM, de Lima AK, Saldiva PHN, Gouveia N. Environmental lead poisoning among children in Porto Alegre State, Southern Brazil. Rev. Saude. Publica. 2012.
https://doi.org/10.1590/S0034-89102012000200004. PMid: 22437855.
WHO. Childhood lead poisoning. In Geneva, Switzerland: World Health Organization; 2010. Available from: https:// www.who.int/ceh/publications/leadguidance.pdf.
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for Lead. In Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service; 2019. Available from: https://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=96&tid=22.
Mukhtar R, Lahtiani S, Hamonangan E, Wahyudi H. Study of quality standards of heavy metals in ambient air as input material appendix Pp 41/1999 concerning air pollution control. 2014; 8(1).
Republic of Indonesia. Indonesian Government Regulation Number 41 of 1999 Concerning Air Pollution Control [Internet]. State Secretariat Indonesia; 1999. Available from: https://peraturan.bpk.go.id/Home/Details/54332/ pp-no-41-tahun-1999.
Ministry of Environment and Forestry of the Republic of Indonesia. The Ministry of Environment and Forestry Has a Landscape Design of Lead Pollution (Pb) in Industrial Estates [Internet]. 2019. Cited on 2020 Sep 23. Available from: http://ppid.menlhk.go.id/, http://ppid.menlhk.go.id/ siaran_pers/browse/2049.
Ministry of Environment and Forestry of the Republic of Indonesia. The Ministry of Environment and Forestry Has a Landscape Design of Lead Pollution (Pb) in Industrial Estates [Internet]. 2019. Cited on 2020 Sep 23. Available from: http://ppid.menlhk.go.id/, http://ppid.menlhk.go.id/ siaran_pers/browse/2049.
Zhang SM, Dai YH, Xie XH, Fan ZY, Tan ZW, Zhang YF. Surveillance of childhood blood lead levels in 14 cities of China in 2004-2006. Biomed. Environ. Sci. 2009. https:// doi.org/10.1016/S0895-3988(09)60058-1.
Wu Y, Yang X, Ge J, Zhang J. Blood lead level and its relationship to certain essential elements in the children aged 0 to 14 years from Beijing, China. Sci. Total Environ. 2011. https://doi.org/10.1016/j.scitotenv.2011.04.050. PMid: 21601238.
Liu J, Liu X, Wang W, McCauley L, Pinto-Martin J, Wang Y, et al. Blood lead concentrations and children's behavioral and emotional problems: A cohort study. JAMA Pediatr. 2014. https://doi.org/10.1001/jamapediatrics.2014.332. PMid: 25090293, PMCid: PMC4152857.
Abu Shady MM, Fathy HA, Fathy GA, Fatah S abd el, Ali A, Abbas MA. Blood lead levels in a group of children: the potential risk factors and health problems. J Pediatr (Versí£o em Port.). 2017. https://doi.org/10.1016/j.jpedp.2017.04.002.
U.S. EPA. Integrated Science Assessment (ISA) for Lead (Final Report, Jul 2013). U.S. Environmental Protection Agency. Washington, DC; 2013.
Tuakuila J, Lison D, Mbuyi F, Haufroid V, Hoet P. Elevated blood lead levels and sources of exposure in the population of Kinshasa, the capital of the Democratic Republic of Congo. J. Expo. Sci. Environ. Epidemiol. 2013. https://doi.org/10.1038/jes.2012.49. PMid: 22617721.
Brink LL, Talbott EO, Sharma RK, Marsh GM, Wu WC, Rager JR, et al. Do us ambient air lead levels have a significant impact on childhood blood lead levels: Results of a national study. J. Environ. Public Health. 2013. https:// doi.org/10.1155/2013/278042. PMid: 23983719, PMCid: PMC3747402.
Schaddelee-Scholten B, Tempowski J. Recycling used lead-acid batteries: Health considerations. United Nations Environment Programme on Safe Management of Used Lead Acid Batteries. 2017.
CPCB. National Ambient Air Quality Standards. Central Pollution Control Board, Government of India New Delhi, India; 2009.
Goldman LR, Schlag RD, Haan M, Kizer KW. Preventing lead poisoning in children. West J. Med. 1990; 152(3): 289-90.
