Review on Bioactive Metabolites of Asparagus racemosus and its Pharmacological Significance

Jump To References Section

Authors

  • Divya
     Supercritical Extraction Laboratory, Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi - 110 016 ,IN
  • Naik S. N.
     Supercritical Extraction Laboratory, Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi - 110 016 ,IN
  • Hariprasad P.
     Environmental Biotechnology Laboratory, Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi - 110 016 ,IN

DOI:

https://doi.org/10.21048/IJND.2023.60.4.34100

Keywords:

Asparagus racemosus, food applications, phytochemicals and pharmacological properties

Abstract

Naturally, genealogical people for different symptoms are nearly new to therapeutic traditional plant active components, Shatavari, a valuable plant growing worldwide. This review provides an overview of Asparagus racemosus and the components of Asparagus racemosus used in entirely new combination of ingredients, have applications in industry as well as medicine. This plant is growing in popularity because to its nutrient-rich root, leaves, blossoms, and fruits. It also has a long history of medical use and is known to possess qualities that are beneficial to medicine. Asparagus racemosus, usually in therapeutic approach for the cancer of the liver, brain disorder, has the main role in milk secretion in pregnant women and regulate sexual behavior. This plant may be a reliable source of bioactive constituents like steroidal saponins, Shatavarins the most important bioactive parts in an exceedingly. A. Racemosus are finding applications due to various potential functions like immunomodulant, galactagogue, antioxidant, anti - inflammatory, antimutagenic, inhibitor, or antiulcer, boosting the lifestyle for humans. Ayurveda suggested it is for interference and treatment of gastrointestinal ulcers, dyspepsia and galactagogue. There has been no scientific proof detected in Shatavari based mostly Nutra beverage considering the range of secondary metabolites present in it their bioavailability and their health advantages. Therefore, the fermentation of Shatavari in Nutra beverages is a developed area of research for the event of different Nutra beverages, which may cause not only supply a lot of nutrition but prevent and therapeutic common diseases additionally.

Downloads

Download data is not yet available.

Downloads

Published

2023-12-01

How to Cite

Divya, S. N., N., & P., H. (2023). Review on Bioactive Metabolites of <i>Asparagus racemosus</i> and its Pharmacological Significance. The Indian Journal of Nutrition and Dietetics, 60(4), 584–597. https://doi.org/10.21048/IJND.2023.60.4.34100

Issue

Volume 60, Issue 4, October-December 2023

Section

Review Articles

License

Copyright (c) 2023 Divya, Naik S. N., Hariprasad P.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All the articles published in IJND are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

Please contact us at editor@informaticsglobal.com for permissions related to commercial use of the article(s).

Crossref
Scopus
Google Scholar
Europe PMC

 

References

Velavan, S., Nagulendran, K.R., Mahesh, R. and Begum, V.H. Plant review the chemistry, pharmacological and therapeutic applications of Asparagus racemosus - A review. Pharma. Rev., 2007, 1, 350-360. https://www.phcogrev.com/sites/default/files/PhcogRev-1-2-350.pdf

Anonymous, The Wealth of India, Raw materials. Publication and Information Directorate, CSIR, N. DELHI, 1987: 468-472. Ayurveda, Volume I. Central Council for Research in Ayurveda and Siddha. Yugantar Prakashan (P.) Ltd., New Delhi, pp.418-430. https://doi.org/10.1016/j.jep.2007.01.001

Kanwar, A.S. and Bhutani, K.K. Effects of Chlorophytum arundinaceum, Asparagus adscendens and Asparagus racemosus on pro-inflammatory cytokine and corticosterone levels produced by stress. Phytother. Res., 2010, 24, 1562-1566. https://doi.org/10.1002/ptr.3218 DOI: https://doi.org/10.1002/ptr.3218

Visavadiya, N.P. and Narasimhacharya, A.V.R.L. Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats. Evidence-Based Complementary and Alternative Med., 2009, 6, 219-226. https://doi.org/10.1093/ecam/nem091 DOI: https://doi.org/10.1093/ecam/nem091

Hannan, J.M.A., Marenah, L., Ali, L., Rokeya, B., Flatt, P.R. and Abdel-Wahab, Y.H. Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells. J. Endocrinol., 2007, 192, 159-168. DOI: 10.1677/joe.1.070840022–0795/07/0192–159 DOI: https://doi.org/10.1677/joe.1.07084

Subha, V., Thulasimuthu, E. and Ilangovan, R. Bactericidal action of copper nanoparticles synthesized from methanolic root extract of Asparagus racemosus. Materials Today: Proceedings, 2022, 64, 1761-1767. https://doi.org/10.1016/j.matpr.2022.06.029 DOI: https://doi.org/10.1016/j.matpr.2022.06.029

Vineetha, V.P., Tejaswi, H.N., Suresh, K., Lekshmi, H., Sneha, K.G., Rakesh, C.G. and Devika, P. Asparagus racemosus improves immune-related parameters in Nile tilapia (Oreochromis niloticus) and mitigates deltamethrin-induced toxicity. Fish & Shellfish Immunology, 2022, 130, 283-293. https://doi.org/10.1016/j.fsi.2022.09.028 DOI: https://doi.org/10.1016/j.fsi.2022.09.028

Singh, S.P., Mehla, R.K. and Singh, M. Plasma hormones, metabolites, milk production, and cholesterol levels in Murrah buffaloes fed with Asparagus racemosus in transition and postpartum period. Tropical Animal Health and Production, 2012, 44, 1827-1832. DOI 10.1007/s11250-012-0144-y DOI: https://doi.org/10.1007/s11250-012-0144-y

Gupta, M. and Shaw, B. A double-blind randomized clinical trial for evaluation of galactogogue activity of Asparagus racemosus Willd. Iranian J. Pharmac. Res. (IJPR), 2011, 10, 167. Google Scholar: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869575/pdf/ijpr-10-167.pdf

Gautam, M., Diwanay, S., Gairola, S., Shinde, Y., Patki, P. and Patwardhan, B. Immuno-adjuvant potential of Asparagus racemosus aqueous extract in experimental system. J. Ethnopharmacol. 2004, 91, 251-255. https://doi.org/10.1016/j.jep.2003.12.023 DOI: https://doi.org/10.1016/j.jep.2003.12.023

Christina, A.J., Ashok, K., Packialakshmi, M., Tobin, G.C., Preethi, J. and Murugesh, N. Antilithiatic effect of Asparagus racemosus Willd on ethylene glycol-induced lithiasis in male albino Wistar rats. Method. Find. Experiment. Clin. pharmacol., 2005, 27, 633-638. DOI: 10.1358/mf.2005.27.9.939338 DOI: https://doi.org/10.1358/mf.2005.27.9.939338

Zhu, X., Zhang, W., Zhao, J., Wang, J. and Qu, W. Hypolipidaemic and hepatoprotective effects of ethanolic and aqueous extracts from Asparagus officinalis L. by-products in mice fed a high-fat diet. J. Sci. Food. Agricul., 2010, 90, 1129-1135. https://doi.org/10.1002/jsfa.3923 DOI: https://doi.org/10.1002/jsfa.3923

Ojha, R., Sahu, A.N., Muruganandam, A.V., Singh, G.K. and Krishnamurthy, S. Asparagus recemosus enhances memory and protects against amnesia in rodent models. Brain and cognition, 2010, 74, 1-9. https://doi.org/10.1016/j.bandc.2010.05.009 DOI: https://doi.org/10.1016/j.bandc.2010.05.009

Sharma, P.C., Yelne, M.B., Dennis, T.J., Joshi, A. and Billore, K.V. Database on medicinal plants used in Ayurveda, 2000. https://agris.fao.org/agris-search/search.do?recordID=US201300132829

Sharma, P., Chauhan, P.S., Dutt, P., Amina, M., Suri, K.A., Gupta, B.D. and Satti, N.K. A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus. Steroids, 2011, 76, 358-364. DOI:10.1016/j.steroids.2010.12.006 DOI: https://doi.org/10.1016/j.steroids.2010.12.006

Thakur, M., Chauhan, N.S., Bhargava, S. and Dixit, V.K. A comparative study on aphrodisiac activity of some ayurvedic herbs in male albino rats. Arc. Sexual Behavior, 2009, 38, 1009-1015. DOI 10.1007/s10508-008-9444-8 DOI: https://doi.org/10.1007/s10508-008-9444-8

Veena, N., Arora, S., Kapila, S., Singh, R.R.B., Katara, A., Pandey, M.M. and Rawat, A.K.S. Immunomodulatory and antioxidative potential of milk fortified with Asparagus racemosus (Shatavari). J. Mech. Phys. Solids, 2014, 2, 13-9. https://www.plantsjournal.com/vol2Issue6/Issue_nov_2014/2.1.pdf

Agrawal, A., Sharma, M., Rai, S.K., Singh, B., Tiwari, M. and Chandra, R. The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine. Phytother. Res., 2008, 22, 1175-1182. https://doi.org/10.1002/ptr.2391 DOI: https://doi.org/10.1002/ptr.2391

Liu, W., Huang, X. F., Qi, Q., Dai, Q.S., Yang, L., Nie, F.F. and Guo, Q.L. Asparanin A induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochem. Biophys. Res. Commun., 2009, 381, 700-705. https://doi.org/10.1016/j.bbrc.2009.02.124 DOI: https://doi.org/10.1016/j.bbrc.2009.02.124

Verma, S.P., Tripathi, V.C. and Das, P. Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: Simultaneous Oncogenic PRCCTFE3 Fusion Transcript Inhibition and Apoptosis independent cell death. Asian Pacific J. Cancer Prevent., 2014, 15, 1937-1941. DOI: http://dx.doi.org/10.7314/APJCP.2014.15.5.1937 DOI: https://doi.org/10.7314/APJCP.2014.15.5.1937

Kaushik, S., Sonone, N.G., Alai, S.P., Tula, S., Pushker, A.K. and Gupta, R. Screening of some medicinally important plants for their antifungal activity against Fusarium oxysporum and Aspergillus parasiticus. Int. J. Herbal Med., 2014, 1, 51-54. Google scholar https://www.florajournal.com/vol2issue1/april2014/2.1.pdf

Kamat, J.P., Boloor, K.K., Devasagayam, T.P. and Venkatachalam, S.R. Antioxidant properties of Asparagus racemosus against damage induced by γ-radiation in rat liver mitochondria. J. Ethnopharmacol., 2000, 71, 425-435. https://doi.org/10.1016/S0378-8741(00)00176-8 DOI: https://doi.org/10.1016/S0378-8741(00)00176-8

Wiboonpun, N., Phuwapraisirisan, P. and Tip-pyang, S. Identification of antioxidant compound from Asparagus racemosus. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2004, 18, 771-773. https://doi.org/10.1002/ptr.1526 DOI: https://doi.org/10.1002/ptr.1526

Thakur, M., Connellan, P., Deseo, M.A., Morris, C., Praznik, W., Loeppert, R. and Dixit, V.K. Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd. Int. J. Biolog. Macromolec., 2012, 50, 77-81. https://doi.org/10.1016/j.ijbiomac.2011.09.027 DOI: https://doi.org/10.1016/j.ijbiomac.2011.09.027

Mandal, S.C., CK, A.K., Lakshmi, S.M., Sinha, S., Murugesan, T., Saha, B.P. and Pal, M. Antitussive effect of Asparagus racemosus root against sulfur dioxide-induced cough in mice. Fitoterapia, 2000, 71, 686-689. https://doi.org/10.1016/S0367-326X(00)00151-9 DOI: https://doi.org/10.1016/S0367-326X(00)00151-9

Singh, G.K., Garabadu, D., Muruganandam, A.V., Joshi, V.K. and Krishnamurthy, S. Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol. Biochem. Behavior, 2009, 91, 283-290. https://doi.org/10.1016/j.pbb.2008.07.010 DOI: https://doi.org/10.1016/j.pbb.2008.07.010

Sharma, K., Bhatnagar, M. and Kulkarni, S.K. Effect of Convolvulus pluricaulis Choisy. and Asparagus racemosus willd on learning and memory in young and old mice: A comparative evaluation, Ind. J. Exp. Biol., 2010, 48, 479-485. https://pubmed.ncbi.nlm.nih.gov/20795365

Kinage, P. and Chaudhari, D. Shatavari: One solution for various female health issues” a review. World J.Pharm. Pharmac. Sci., 2016, 5, 1105-4. DOI: 10.20959/wjpps20165-6688

Mangal, A., Panda, D. and Sharma, M.C. Peptic ulcer healing properties of Shatavari (Asparagus racemosus Willd.), 2006.

Sairam, K., Priyambada, S., Aryya, N.C. and Goel, R.K. Gastroduodenal ulcer protective activity of Asparagus racemosus: An experimental, biochemical and histological study. J. Ethnopharmacol., 2003, 86, 1-10. https://doi.org/10.1016/S0378-8741(02)00342-2 DOI: https://doi.org/10.1016/S0378-8741(02)00342-2

Joshi, S. and Thatte, U. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. National J.Physiol. Pharma. Pharmacol., 1970, 2, 172-172. DOI: 10.5455/njppp.2012.2.172-178 DOI: https://doi.org/10.5455/njppp.2012.2.172-178

Sharma, U., Kumar, N., Singh, B., Munshi, R.K. and Bhalerao, S. Immunomodulatory active steroidal saponins from Asparagus racemosus. Med. Chem. Res., 2013, 22, 573-579. DOI: 10.1007/s00044-012-0048-4 DOI: https://doi.org/10.1007/s00044-012-0048-4

Reddy, S.L. and Endo, T. Spectroscopic studies on Satavari root and Amla. Transact. Mat. Res. Society of Japan, 2010, 35, 519-527. https://doi.org/10.14723/tmrsj.35.519 DOI: https://doi.org/10.14723/tmrsj.35.519

Bopana, N. and Saxena, S. Asparagus racemosus - Ethnopharmacological evaluation and conservation needs. J. Ethnopharmacol., 2007, 110, 1-15. https://doi.org/10.1016/j.jep.2007.01.001 DOI: https://doi.org/10.1016/j.jep.2007.01.001

Gyawali, R. and Kim, K.S. Bioactive volatile compounds of three medicinal plants from Nepal. Kathmandu University J. Sci., Engin. Technol., 2012, 8, 51-62. DOI: https://doi.org/10.3126/kuset.v8i1.6043 DOI: https://doi.org/10.3126/kuset.v8i1.6043

Hayes, P.Y., Jahidin, A.H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J.J. Steroidal saponins from the roots of Asparagus racemosus. Phytochem., 2008, 69, 796-804. https://doi.org/10.1016/j.phytochem.2007.09.001. DOI: https://doi.org/10.1016/j.phytochem.2007.09.001

Hayes, P. Y., Jahidin, A.H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J.J. Asparinins, asparosides, curillins, curillosides and shavatarins: Structural clarification with the isolation of shatavarin V, A new steroidal saponin from the root of Asparagus racemosus. Tetrahedron letters, 2006, 47, 8683-8687. https://doi.org/10.1016/j.tetlet.2006.10.030 DOI: https://doi.org/10.1016/j.tetlet.2006.10.030

Singh, N., Jha, A., Chaudhary, A. and Upadhyay, A. Enhancement of the functionality of bread by incorporation of Shatavari (Asparagus racemosus). J. Food Sci. Technol, 2014, 51, 2038-2045. DOI: 10.1007/s13197-012-0731-y DOI: https://doi.org/10.1007/s13197-012-0731-y

Mehta, M. Development of low cost nutritive biscuits with Ayurvedic formulation. International J. Ayurvedic and Herbal Med., 2013, 3, 1183. Google scholar https://interscience.org.uk/v3-i3/3%20ijahm.pdf